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Development 129, 3815-3823 (2002)
© 2002 The Company of Biologists Limited

Dpp signalling is a key effector of the wing-body wall subdivision of the Drosophila mesothorax

Florencia Cavodeassi*, Isabel Rodríguez and Juan Modolell{ddagger}

Centro de Biología Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain
* Present address: Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK

{ddagger}Author for correspondence (e-mail: jmodol{at}cbm.uam.es)

Accepted 22 May 2002

During development, the imaginal wing disc of Drosophila is subdivided along the proximal-distal axis into different territories that will give rise to body wall (notum and mesothoracic pleura) and appendage (wing hinge and wing blade). Expression of the Iroquois complex (Iro-C) homeobox genes in the most proximal part of the disc defines the notum, since Iro-C– cells within this territory acquire the identity of the adjacent distal region, the wing hinge. Here we analyze how the expression of Iro-C is confined to the notum territory. Neither Wingless signalling, which is essential for wing development, nor Vein-dependent EGFR signalling, which is needed to activate Iro-C, appear to delimit Iro-C expression. We show that a main effector of this confinement is the TGFß homolog Decapentaplegic (Dpp), a molecule known to pattern the disc along its anterior-posterior axis. At early second larval instar, the Dpp signalling pathway functions only in the wing and hinge territories, represses Iro-C and confines its expression to the notum territory. Later, Dpp becomes expressed in the most proximal part of the notum and turns off Iro-C in this region. This downregulation is associated with the subdivision of the notum into medial and lateral regions.

Key words: Iroquois complex, Dpp signalling, Imaginal wing disc, Notum development, Drosophila melanogaster


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© The Company of Biologists Ltd 2002