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Development 129, 4271-4280 (2002)
© 2002 The Company of Biologists Limited

Eye suppression, a novel function of teashirt, requires Wingless signaling

Amit Singh, Madhuri Kango-Singh and Y. Henry Sun*

Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, 11529 Taiwan, Republic of China

*Author for correspondence (e-mail: mbyhsun{at}ccvax.sinica.edu.tw)

Accepted 14 May 2002

teashirt (tsh) encodes a Drosophila zinc-finger protein. Misexpression of tsh has been shown to induce ectopic eye formation in the antenna. We report that tsh can suppress eye development. This novel function of tsh is due to the induction of homothorax (hth), a known repressor of eye development, and requires Wingless (WG) signaling. Interestingly, tsh has different functions in the dorsal and ventral eye, suppressing eye development close to the ventral margin, while promoting eye development near the dorsal margin. It affects both growth of eye disc and retinal cell differentiation.

Key words: Drosophila, Eye, teashirt, WG


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© The Company of Biologists Ltd 2002