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1 Department of Genetic Engineering, Kyungpook National University, Daegu 702-701, Korea
2 TG Biotech, KNU Technopark, Kyungpook National University, Daegu 702-701, Korea
3 Department of Biology, Chungnam National University, Daejeon 305-764, Korea
4 Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
*Author for correspondence (e-mail: tlhuh{at}knu.ac.kr)
Accepted 25 June 2002
Wnts have been shown to provide a posteriorizing signal that has to be repressed in the anterior neuroectoderm for normal anteroposterior (AP) patterning. We have previously identified a zebrafish frizzled8a (fz8a) gene expressed in the presumptive anterior neuroectoderm as well as prechordal plate at the late gastrula stage. We have investigated the role of Fz8a-mediated Wnt8b signalling in anterior brain patterning in zebrafish. We show that in zebrafish embryos: (1) Wnt signalling has at least two different stage-specific posteriorizing activities in the anterior neuroectoderm, one before mid-gastrulation and the other at late gastrulation; (2) Fz8a plays an important role in mediating anterior brain patterning; (3) Wnt8b and Fz8a can functionally interact to transmit posteriorizing signals that determine the fate of the posterior diencephalon and midbrain in late gastrula embryos; and (4) Wnt8b can suppress fz8a expression in the anterior neuroectoderm and potentially affect the level and/or range of Wnt signalling. In conclusion, we suggest that a gradient of Fz8a-mediated Wnt8b signalling may play crucial role in patterning the posterior diencephalon and midbrain regions in the late gastrula.
Key words: Fz8a, Wnt8b, Anterior neuroectoderm, Brain patterning, Eye primordia, Diencephalon, Midbrain, Zebrafish
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