|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Department of Molecular Biology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
*Author for correspondence (e-mail: sh3312{at}med.yokohama-cu.ac.jp)
Accepted 27 June 2002
The radial migration of differentiating neurons provides an essential step in the generation of laminated neocortex, although its molecular mechanism is not fully understood. We show that the protein levels of a JNK activator kinase, MUK/DLK/ZPK, and JNK activity increase potently and temporally in newly generated neurons in developing mouse telencephalon during radial migration. The ectopic expression of MUK/DLK/ZPK in neural precursor cells in utero impairs radial migration, whereas it allows these cells to leave the ventricular zone and differentiate into neural cells. The MUK/DLK/ZPK protein is associated with dotted structures that are frequently located along microtubules and with Golgi apparatus in cultured embryonic cortical cells. In COS-1 cells, MUK/DLK/ZPK overexpression impairs the radial organization of microtubules without massive depolymerization. These results suggest that MUK/DLK/ZPK and JNK regulate radial cell migration via microtubule-based events.
Key words: Cortex, JNK, Microtubules, Mouse
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  E. S. Tucker, S. Segall, D. Gopalakrishna, Y. Wu, M. Vernon, F. Polleux, and A.-S. LaMantia Molecular Specification and Patterning of Progenitor Cells in the Lateral and Medial Ganglionic Eminences J. Neurosci., September 17, 2008; 28(38): 9504 - 9518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Handley, J. Rasaiyaah, J. Barnett, M. Thakker, G. Pollara, D. R. Katz, and B. M. Chain Expression and function of mixed lineage kinases in dendritic cells Int. Immunol., August 13, 2007; (2007) dxm050v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Hirai, D. Feng Cui, T. Miyata, M. Ogawa, H. Kiyonari, Y. Suda, S. Aizawa, Y. Banba, and S. Ohno The c-Jun N-Terminal Kinase Activator Dual Leucine Zipper Kinase Regulates Axon Growth and Neuronal Migration in the Developing Cerebral Cortex. J. Neurosci., November 15, 2006; 26(46): 11992 - 12002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tararuk, N. Ostman, W. Li, B. Bjorkblom, A. Padzik, J. Zdrojewska, V. Hongisto, T. Herdegen, W. Konopka, M. J. Courtney, et al. JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length J. Cell Biol., April 24, 2006; 173(2): 265 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Mizuno, H. Kokubu, M. Sato, A. Nishimura, J. Yamauchi, H. Kurose, and H. Itoh G protein-coupled receptor signaling through Gq and JNK negatively regulates neural progenitor cell migration PNAS, August 30, 2005; 102(35): 12365 - 12370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kanatani, H. Tabata, and K. Nakajima Topical Review: Neuronal Migration in Cortical Development J Child Neurol, April 1, 2005; 20(4): 274 - 279. [Abstract] [PDF]
|
|
|
|
|
|
S. Kanatani, H. Tabata, and K. Nakajima Topical Review: Neuronal Migration in Cortical Development J Child Neurol, March 1, 2004; 19(3): 274 - 279. [Abstract] [PDF]
|
|
|
|
|
|
N. Kelkar, M.-H. Delmotte, C. R. Weston, T. Barrett, B. J. Sheppard, R. A. Flavell, and R. J. Davis Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3) PNAS, August 19, 2003; 100(17): 9843 - 9848. [Abstract] [Full Text] [PDF]
|
|
