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Development 129, 4797-4806 (2002)
Copyright © 2002 The Company of Biologists Limited

Abnormal lymphatic vessel development in neuropilin 2 mutant mice

Li Yuan1, Delphine Moyon1, Luc Pardanaud1, Christiane Bréant1, Marika J. Karkkainen2, Kari Alitalo2 and Anne Eichmann1,*

1 INSERM U36, Collège de France, 11, place Marcelin Berthelot, 75005 Paris, France
2 Molecular/Cancer Biology Laboratory, Biomedicum Helsinki, 00014 Helsinki, Finland

*Author for correspondence (e-mail: anne.eichmann{at}college-de-france.fr)

Accepted 11 July 2002

Neuropilin 2 is a receptor for class III semaphorins and for certain members of the vascular endothelial growth factor family. Targeted inactivation of the neuropilin 2 gene (Nrp2) has previously shown its role in neural development. We report that neuropilin 2 expression in the vascular system is restricted to veins and lymphatic vessels. Homozygous Nrp2 mutants show absence or severe reduction of small lymphatic vessels and capillaries during development. This correlated with a reduction of DNA synthesis in the lymphatic endothelial cells of the mutants. Arteries, veins and larger, collecting lymphatic vessels developed normally, suggesting that neuropilin 2 is selectively required for the formation of small lymphatic vessels and capillaries.

Key words: Endothelial cell, Growth factor receptor, Lymphangiogenesis, Mouse






© The Company of Biologists Ltd 2002