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Development 129, 4953-4962 (2002)
Copyright © 2002 The Company of Biologists Limited

Amphioxus and lamprey AP-2 genes: implications for neural crest evolution and migration patterns

Daniel Meulemans and Marianne Bronner-Fraser*

Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA

* Author for correspondence (e-mail: mbronner{at}caltech.edu)

Accepted 30 July 2002

The neural crest is a uniquely vertebrate cell type present in the most basal vertebrates, but not in cephalochordates. We have studied differences in regulation of the neural crest marker AP-2 across two evolutionary transitions: invertebrate to vertebrate, and agnathan to gnathostome. Isolation and comparison of amphioxus, lamprey and axolotl AP-2 reveals its extensive expansion in the vertebrate dorsal neural tube and pharyngeal arches, implying co-option of AP-2 genes by neural crest cells early in vertebrate evolution. Expression in non-neural ectoderm is a conserved feature in amphioxus and vertebrates, suggesting an ancient role for AP-2 genes in this tissue. There is also common expression in subsets of ventrolateral neurons in the anterior neural tube, consistent with a primitive role in brain development. Comparison of AP-2 expression in axolotl and lamprey suggests an elaboration of cranial neural crest patterning in gnathostomes. However, migration of AP-2-expressing neural crest cells medial to the pharyngeal arch mesoderm appears to be a primitive feature retained in all vertebrates. Because AP-2 has essential roles in cranial neural crest differentiation and proliferation, the co-option of AP-2 by neural crest cells in the vertebrate lineage was a potentially crucial event in vertebrate evolution.

Key words: AP-2, Amphioxus, Lamprey, Neural crest, Migration


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© The Company of Biologists Ltd 2002