|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
doi: 10.1242/10.1242/dev.00116
Institute of Signaling, Developmental Biology and Cancer, UMR 6543 — CNRS, Parc Valrose, 06108 NICE cedex 2, France
Author for correspondence (e-mail:
noselli{at}unice.fr)
Accepted 30 August 2002
In mammals, the JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) signaling pathway is activated in response to cytokines and growth factors to control blood cell development, proliferation and cell determination. In Drosophila, a conserved JAK/STAT signaling pathway controls segmentation in embryos, as well as blood cell development and other processes in larvae and adults. During embryogenesis, transduction of the Unpaired [Upd; also known as Outstretched (Os)] ligand through the JAK/STAT pathway requires Domeless, a putative membrane protein with distant homology to vertebrate type I cytokine receptors. We have isolated domeless (dome) in a screen to identify genes essential in epithelial morphogenesis during oogenesis. The level of dome activity is critical for proper border cell migration and is controlled in part through a negative feedback loop. In addition to its essential role in border cells, we show that dome is required in the germarium for the polarization of follicle cells during encapsulation of germline cells. In this process, dome controls the expression of the apical determinant Crumbs. In contrast to the ligand Upd, whose expression is limited to a pair of polar cells at both ends of the egg chamber, dome is expressed in all germline and follicle cells. However, the Dome protein is specifically localized at apicolateral membranes and undergoes ligand-dependent internalization in the follicle cells. dome mutations interact genetically with JAK/STAT pathway genes in border cell migration and abolish the nuclear translocation of Stat92E in vivo. We also show that dome functions downstream of upd and that both the extracellular and intracellular domains of Dome are required for JAK/STAT signaling. Altogether, our data indicate that Dome is an essential receptor molecule for Upd and JAK/STAT signaling during oogenesis.
Key words: JAK/STAT pathway, Cytokine, Crumbs, Border cells, Follicle cells, Egg chamber, Drosophila melanogaster
This article has been cited by other articles:
|
|
 |
|
  G. Nallamothu, J. A. Woolworth, V. Dammai, and T. Hsu awd, the Homolog of Metastasis Suppressor Gene Nm23, Regulates Drosophila Epithelial Cell Invasion Mol. Cell. Biol., March 15, 2008; 28(6): 1964 - 1973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Devergne, C. Ghiglione, and S. Noselli The endocytic control of JAK/STAT signalling in Drosophila J. Cell Sci., October 1, 2007; 120(19): 3457 - 3464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Furriols, G. Ventura, and J. Casanova Two distinct but convergent groups of cells trigger Torso receptor tyrosine kinase activation by independently expressing torso-like PNAS, July 10, 2007; 104(28): 11660 - 11665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Assa-Kunik, I. L. Torres, E. D. Schejter, D. S. Johnston, and B.-Z. Shilo Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways Development, March 15, 2007; 134(6): 1161 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. I. Arbouzova and M. P. Zeidler JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions. Development, July 1, 2006; 133(14): 2605 - 2616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wood, C. Faria, and A. Jacinto Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster J. Cell Biol., May 8, 2006; 173(3): 405 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O Huising, C. P Kruiswijk, and G. Flik Phylogeny and evolution of class-I helical cytokines. J. Endocrinol., April 1, 2006; 189(1): 1 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Bao, W. Zhang, R. Krencik, H. Deng, Y. Wang, J. Girton, J. Johansen, and K. M. Johansen The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells J. Cell Sci., November 1, 2005; 118(21): 5079 - 5087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Silver, E. R. Geisbrecht, and D. J. Montell Requirement for JAK/STAT signaling throughout border cell migration in Drosophila Development, August 1, 2005; 132(15): 3483 - 3492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Medioni and S. Noselli Dynamics of the basement membrane in invasive epithelial clusters in Drosophila Development, July 1, 2005; 132(13): 3069 - 3077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Andl, T. Mizushima, K. Oyama, M. Bowser, H. Nakagawa, and A. K. Rustgi EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes Am J Physiol Gastrointest Liver Physiol, December 1, 2004; 287(6): G1227 - G1237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Brown, N. Hu, and J. C.-G. Hombria Novel level of signalling control in the JAK/STAT pathway revealed by in situ visualisation of protein-protein interaction during Drosophila development Development, July 15, 2003; 130(14): 3077 - 3084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ben-Shlomo, S. Yu Hsu, R. Rauch, H. W. Kowalski, and A. J. W. Hsueh Signaling Receptome: A Genomic and Evolutionary Perspective of Plasma Membrane Receptors Involved in Signal Transduction Sci. Signal., June 17, 2003; 2003(187): re9 - re9. [Abstract] [Full Text] [PDF]
|
|
