QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Williams, D. W. Articles by Shepherd, D. Search for Related Content PubMed PubMed Citation Articles by Williams, D. W. Articles by Shepherd, D. Social Bookmarking                         What's this?

Persistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila

Darren W. Williams^* and David Shepherd

School of Biological Sciences, University of Southampton, Southampton, SO16 7PX, UK
^* Present address: Department of Zoology, University of Washington, Seattle, WA 98195, USA

Author for correspondence (e-mail: ds{at}soton.ac.uk)

Accepted 2 November 2001

We have tested the hypothesis that larval neurones guide growth of adult sensory axons in Drosophila. We show that ablation of larval sensory neurones causes defects in the central projections of adult sensory neurones. Spiralling axons and ectopic projections indicate failure in axon growth guidance. We show that larval sensory neurones are required for peripheral pathfinding, entry into the CNS and growth guidance within the CNS. Ablation of subsets of neurones shows that larval sensory neurones serve specific guidance roles. Dorsal neurones are required for axon guidance across the midline, whereas lateral neurones are required for posterior growth. We conclude that larval sensory neurones pioneer the assembly of sensory arrays in adults.

Key words: Laser ablation, Axon guidance, Metamorphosis, Drosophila

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. J. Pittman, M.-Y. Law, and C.-B. Chien Pathfinding in a large vertebrate axon tract: isotypic interactions guide retinotectal axons at multiple choice points Development, September 1, 2008; 135(17): 2865 - 2871. [Abstract] [Full Text] [PDF]

				B. Gerber and R. F. Stocker The Drosophila Larva as a Model for Studying Chemosensation and Chemosensory Learning: A Review Chem Senses, January 1, 2007; 32(1): 65 - 89. [Abstract] [Full Text] [PDF]

				D. W. Williams and J. W. Truman Cellular mechanisms of dendrite pruning in Drosophila: insights from in vivo time-lapse of remodeling dendritic arborizing sensory neurons Development, August 15, 2005; 132(16): 3631 - 3642. [Abstract] [Full Text] [PDF]

				N. Sanchez-Soriano and A. Prokop The Influence of Pioneer Neurons on a Growing Motor Nerve in Drosophila Requires the Neural Cell Adhesion Molecule Homolog FasciclinII J. Neurosci., January 5, 2005; 25(1): 78 - 87. [Abstract] [Full Text] [PDF]

				D. W. Williams and J. W. Truman Mechanisms of Dendritic Elaboration of Sensory Neurons in Drosophila: Insights from In Vivo Time Lapse J. Neurosci., February 18, 2004; 24(7): 1541 - 1550. [Abstract] [Full Text] [PDF]

				N. Gendre, K. Luer, S. Friche, N. Grillenzoni, A. Ramaekers, G. M. Technau, and R. F. Stocker Integration of complex larval chemosensory organs into the adult nervous system of Drosophila Development, January 1, 2004; 131(1): 83 - 92. [Abstract] [Full Text] [PDF]