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Development 129, 671-680 (2002)
© 2002 The Company of Biologists Limited

Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system

Takahiko Kawasaki1,2,*, Yoko Bekku1,*, Fumikazu Suto1,2, Takashi Kitsukawa3, Masahiko Taniguchi5, Ikuko Nagatsu6, Toshiharu Nagatsu7, Kazuo Itoh8, Takeshi Yagi2,4 and Hajime Fujisawa1,2,{dagger}

1 Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa-ku, Nagoya 464-8602, and
2 CREST, JST (Japan Science and Technology Corporation), 4-1-8 Honcho, Kawaguchi-shi, Saitama 332-0012, Japan
3 Laboratory of Specification Mechanisms 1, National Institute for Basic Biology, and
4 Laboratory of Neurobiology and Behavioral Genetics, National Institute for Physiological Science, Myodaiji, Okazaki 444, Japan
5 Department of Biochemical and Molecular Biology, Graduate School of Medicine, Tokyo University, Hongo, Tokyo 113-0033, Japan
6 Department of Anatomy and
7 Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University, Toyoake, Aichi 470-11, Japan
8 Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Machikaneyama 1-16, Osaka 560-0043, Japan
* These authors equally contributed to the paper

{dagger} Author for correspondence (e-mail: fujisawa{at}bio.nagoya-u.ac.jp)

Accepted 30 October 2001

Neuropilin 1 is the specific receptor for Sema3A and plays a role in nerve fiber guidance. We report that neuropilin 1 and Sema3A mutant mouse embryos, generated by targeted gene disruption, showed displacement of sympathetic neurons and their precursors and abnormal morphogenesis in the sympathetic trunk. We also show that Sema3A suppressed the cell migration activity of sympathetic neurons from wild-type but not neuropilin 1 mutant embryos in vitro and instead promoted their accumulation into compact cell masses and fasciculation of their neurites. These findings suggest that the neuropilin 1-mediated Sema3A signals regulate arrest and aggregation of sympathetic neuron precursors and sympathetic neurons themselves at defined target sites and axon fasciculation to produce the stereotyped sympathetic nerve pattern.

Key words: Cell migration, Axon fasciculation, Neural crest, Sympathetic neurons, Sympathetic ganglia, Sympathetic trunk, neuropilin 1 mutant mice, Sema3A mutant mice


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© The Company of Biologists Ltd 2002