|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
University of Kentucky, T. H. Morgan School of Biological Sciences, 101 Morgan Building, Lexington, KY 40506, USA
*Author for correspondence (e-mail: DougH{at}uky.edu)
Accepted 6 November 2001
Janus kinase (JAK) pathway activity is an integral part of signaling through a variety of ligands and receptors in mammals. The extensive re-utilization and pleiotropy of this pathway in vertebrate development is conserved in other animals as well. In Drosophila melanogaster, JAK signaling has been implicated in embryonic pattern formation, sex determination, larval blood cell development, wing venation, planar polarity in the eye, and formation of other adult structures. Here we describe several roles for JAK signaling in Drosophila oogenesis. The gene for a JAK pathway ligand, unpaired, is expressed specifically in the polar follicle cells, two pairs of somatic cells at the anterior and posterior poles of the developing egg chamber. Consistent with unpaired expression, reduced JAK pathway activity results in the fusion of developing egg chambers. A primary defect of these chambers is the expansion of the polar cell population and concomitant loss of interfollicular stalk cells. These phenotypes are enhanced by reduction of unpaired activity, suggesting that Unpaired is a necessary ligand for the JAK pathway in oogenesis. Mosaic analysis of both JAK pathway transducers, hopscotch and Stat92E, reveals that JAK signaling is specifically required in the somatic follicle cells. Moreover, JAK activity is also necessary for the initial commitment of epithelial follicle cells. Many of these roles are in common with, but distinct from, the known functions of Notch signaling in oogenesis. Consistent with these data is a model in which Notch signaling determines a pool of cells to be competent to adopt stalk or polar fate, while JAK signaling assigns specific identity within that competent pool.
Key words: Drosophila, JAK, Oogenesis, Follicle cells, Notch
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Furriols, G. Ventura, and J. Casanova Two distinct but convergent groups of cells trigger Torso receptor tyrosine kinase activation by independently expressing torso-like PNAS, July 10, 2007; 104(28): 11660 - 11665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Assa-Kunik, I. L. Torres, E. D. Schejter, D. S. Johnston, and B.-Z. Shilo Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways Development, March 15, 2007; 134(6): 1161 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. I. Arbouzova and M. P. Zeidler JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions. Development, July 1, 2006; 133(14): 2605 - 2616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Mukherjee, U. Schafer, and M. P. Zeidler Identification of Drosophila Genes Modulating Janus Kinase/Signal Transducer and Activator of Transcription Signal Transduction Genetics, March 1, 2006; 172(3): 1683 - 1697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Silver, E. R. Geisbrecht, and D. J. Montell Requirement for JAK/STAT signaling throughout border cell migration in Drosophila Development, August 1, 2005; 132(15): 3483 - 3492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Medioni and S. Noselli Dynamics of the basement membrane in invasive epithelial clusters in Drosophila Development, July 1, 2005; 132(13): 3069 - 3077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Adam and D. J. Montell A role for extra macrochaetae downstream of Notch in follicle cell differentiation Development, December 1, 2004; 131(23): 5971 - 5980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gaziova, P. C. Bonnette, V. C. Henrich, and M. Jindra Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis Development, June 1, 2004; 131(11): 2715 - 2725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Narbonne, F. Besse, J. Brissard-Zahraoui, A.-M. Pret, and D. Busson polyhomeotic is required for somatic cell proliferation and differentiation during ovarian follicle formation in Drosophila Development, March 15, 2004; 131(6): 1389 - 1400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Bach, S. Vincent, M. P. Zeidler, and N. Perrimon A Sensitized Genetic Screen to Identify Novel Regulators and Components of the Drosophila Janus Kinase/Signal Transducer and Activator of Transcription Pathway Genetics, November 1, 2003; 165(3): 1149 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Grammont and K. D. Irvine Organizer activity of the polar cells during Drosophila oogenesis Development, March 13, 2003; 129(22): 5131 - 5140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Besse and A.-M. Pret Apoptosis-mediated cell death within the ovarian polar cell lineage of Drosophila melanogaster Development, March 1, 2003; 130(5): 1017 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bai and D. Montell Eyes Absent, a key repressor of polar cell fate during Drosophila oogenesis Development, January 12, 2002; 129(23): 5377 - 5388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ghiglione, O. Devergne, E. Georgenthum, F. Carballes, C. Medioni, D. Cerezo, and S. Noselli The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis Development, January 12, 2002; 129(23): 5437 - 5447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Smith III, C. A. Cummings, and C. Cronmiller daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila Development, January 7, 2002; 129(13): 3255 - 3267. [Abstract] [Full Text] [PDF]
|
|
