spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mui, S. H.
Right arrow Articles by Bertuzzi, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mui, S. H.
Right arrow Articles by Bertuzzi, S.
Development 129, 797-804 (2002)
© 2002 The Company of Biologists Limited

The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye

Stina H. Mui1,2, Robert Hindges1, Dennis D. M. O’Leary1, Greg Lemke1,* and Stefano Bertuzzi1,{dagger}

1 Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037 USA
2 Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 USA
{dagger} Present address: Telethon Foundation at CNR Istituto Tecnologie Biomediche, 20090 Segrate (Milan), Italy

*Author for correspondence (e-mail: lemke{at}salk.edu)

Accepted 6 November 2001

The vertebrate retina is highly ordered along both its dorsoventral (DV) and nasotemporal (NT) axes, and this order is topographically maintained in its axonal connections to the superior colliculus of the midbrain. Although the graded axon guidance cues that mediate the topographic mapping of retinocollicular connections are increasingly well understood, the transcriptional regulators that set the DV and NT gradients of these cues are not. We now provide genetic evidence that Vax2, a homeodomain protein expressed in the ventral retina, is one such regulator. We demonstrate that in Vax2 mutant mice, retinocollicular projections from the ventral temporal retina are dorsalized relative to wild type. Remarkably, however, this dorsalization becomes systematically less severe in progressively more nasal regions of the ventral retina. Vax2 mutants also exhibit flattened DV and NT gradients of the EphA5, EphB2, EphB3, ephrin-B1 and ephrin-B2 axon guidance cues. Together, these data identify Vax2 as a fundamental regulator of axial polarization in the mammalian retina.

Key words: Retina, Homeobox, Vax genes, Emx genes, Dorsoventral axis, Axon guidance, Mouse




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
D. T. Plas, O. S. Dhande, J. E. Lopez, D. Murali, C. Thaller, M. Henkemeyer, Y. Furuta, P. Overbeek, and M. C. Crair
Bone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse
J. Neurosci., July 9, 2008; 28(28): 7057 - 7067.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Garcia-Frigola, M. I. Carreres, C. Vegar, C. Mason, and E. Herrera
Zic2 promotes axonal divergence at the optic chiasm midline by EphB1-dependent and -independent mechanisms
Development, May 15, 2008; 135(10): 1833 - 1841.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
T. Harada, C. Harada, and L. F. Parada
Molecular regulation of visual system development: more than meets the eye
Genes & Dev., February 15, 2007; 21(4): 367 - 378.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. J. Butler and G. Tear
Getting axons onto the right path: the role of transcription factors in axon guidance
Development, February 1, 2007; 134(3): 439 - 448.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Sakuta, H. Takahashi, T. Shintani, K. Etani, A. Aoshima, and M. Noda
Role of bone morphogenic protein 2 in retinal patterning and retinotectal projection.
J. Neurosci., October 18, 2006; 26(42): 10868 - 10878.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. W. Kim and G. Lemke
Hedgehog-regulated localization of Vax2 controls eye development.
Genes & Dev., October 15, 2006; 20(20): 2833 - 2847.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Q. Ma
Transcriptional regulation of neuronal phenotype in mammals
J. Physiol., September 1, 2006; 575(2): 379 - 387.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Morcillo, J. R. Martinez-Morales, F. Trousse, Y. Fermin, J. C. Sowden, and P. Bovolenta
Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH
Development, August 15, 2006; 133(16): 3179 - 3190.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Molotkov, N. Molotkova, and G. Duester
Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning
Development, May 15, 2006; 133(10): 1901 - 1910.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Sen, S. Harpavat, M. A. Peters, and C. L. Cepko
Retinoic acid regulates the expression of dorsoventral topographic guidance molecules in the chick retina
Development, December 1, 2005; 132(23): 5147 - 5159.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Picker and M. Brand
Fgf signals from a novel signaling center determine axial patterning of the prospective neural retina
Development, November 15, 2005; 132(22): 4951 - 4962.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
S. H. Mui, J. W. Kim, G. Lemke, and S. Bertuzzi
Vax genes ventralize the embryonic eye
Genes & Dev., May 15, 2005; 19(10): 1249 - 1259.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
G. Alfano, C. Vitiello, C. Caccioppoli, T. Caramico, A. Carola, M. J. Szego, R. R. McInnes, A. Auricchio, and S. Banfi
Natural antisense transcripts associated with genes involved in eye development
Hum. Mol. Genet., April 1, 2005; 14(7): 913 - 923.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Lupo, Y. Liu, R. Qiu, R. A. S. Chandraratna, G. Barsacchi, R.-Q. He, and W. A. Harris
Dorsoventral patterning of the Xenopus eye: a collaboration of Retinoid, Hedgehog and FGF receptor signaling
Development, April 1, 2005; 132(7): 1737 - 1748.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Schulte, M. A. Peters, J. Sen, and C. L. Cepko
The Rod Photoreceptor Pattern Is Set at the Optic Vesicle Stage and Requires Spatially Restricted cVax Expression
J. Neurosci., March 16, 2005; 25(11): 2823 - 2831.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Murali, S. Yoshikawa, R. R. Corrigan, D. J. Plas, M. C. Crair, G. Oliver, K. M. Lyons, Y. Mishina, and Y. Furuta
Distinct developmental programs require different levels of Bmp signaling during mouse retinal development
Development, March 1, 2005; 132(5): 913 - 923.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Leconte, L. Lecoin, P. Martin, and S. Saule
Pax6 Interacts with cVax and Tbx5 to Establish the Dorsoventral Boundary of the Developing Eye
J. Biol. Chem., November 5, 2004; 279(45): 47272 - 47277.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. Taglialatela, J. M. Soria, V. Caironi, A. Moiana, and S. Bertuzzi
Compromised generation of GABAergic interneurons in the brains of Vax1-/- mice
Development, September 1, 2004; 131(17): 4239 - 4249.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Pratt, N. M. M.-L. Tian, T. I. Simpson, J. O. Mason, and D. J. Price
The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse
Development, August 1, 2004; 131(15): 3773 - 3784.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Zhang, Z. Jin, and Z.-Z. Bao
Disruption of gradient expression of Zic3 resulted in abnormal intra-retinal axon projection
Development, April 1, 2004; 131(7): 1553 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
K. K. Murai and E. B. Pasquale
`Eph'ective signaling: forward, reverse and crosstalk
J. Cell Sci., July 15, 2003; 116(14): 2823 - 2832.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. McLaughlin, R. Hindges, P. A. Yates, and D. D. M. O'Leary
Bifunctional action of ephrin-B1 as a repellent and attractant to control bidirectional branch extension in dorsal-ventral retinotopic mapping
Development, June 1, 2003; 130(11): 2407 - 2418.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Weinl, U. Drescher, S. Lang, F. Bonhoeffer, and J. Loschinger
On the turning of Xenopus retinal axons induced by ephrin-A5
Development, April 15, 2003; 130(8): 1635 - 1643.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Take-uchi, J. D. W. Clarke, and S. W. Wilson
Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity
Development, March 1, 2003; 130(5): 955 - 968.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. P. Demyanenko and P. F. Maness
The L1 Cell Adhesion Molecule Is Essential for Topographic Mapping of Retinal Axons
J. Neurosci., January 15, 2003; 23(2): 530 - 538.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Baumer, T. Marquardt, A. Stoykova, R. Ashery-Padan, K. Chowdhury, and P. Gruss
Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle
Development, January 10, 2002; 129(19): 4535 - 4545.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2002