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Development 129, 965-972 (2002)
© 2002 The Company of Biologists Limited

Mice that lack astrotactin have slowed neuronal migration

Niels C. Adams1, Toshifumi Tomoda1, Margaret Cooper1, Gunnar Dietz2 and Mary E. Hatten1,*

1 Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA
2 Medizinische Fakultät, Neurologische Universitätsklinik, Hoppe-Seyler-Straße 3, D-72076 Tübingen, Germany

*Author for correspondence (e-mail: hatten{at}rockefeller.edu)

Accepted 19 November 2001

The cortical regions of the brain are laminated as a result of directed migration of precursor cells along glia during development. Previously, we have used an assay system to identify astrotactin as a neuronal ligand for migration on glial fibers. To examine the function of astrotactin in vivo, we generated a null mutation by targeted gene disruption. The cerebella of astrotactin null mice are approximately 10% smaller than wild type. In vitro and in vivo cerebellar granule cell assays show a decrease in neuron-glial binding, a reduction in migration rates and abnormal development of Purkinje cells. Consequences of this are poorer balance and coordination. Thus, astrotactin functions in migration along glial processes in vivo, a process required for generating laminar structures and for the development of synaptic partner systems.

Key words: Mouse, Cerebellum, Granule Cell, Purkinje Cell, Bergmann Glia, Behavior




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