spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Erkner, A.
Right arrow Articles by Kerridge, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Erkner, A.
Right arrow Articles by Kerridge, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Development 129, 1119-1129 (2002)
© 2002 The Company of Biologists Limited

Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development

Alfrun Erkner*, Agnès Roure, Bernard Charroux, Michèle Delaage, Nicolas Holway, Nathalie Coré, Christine Vola, Corinne Angelats, Françoise Pagès, Laurent Fasano and Stephen Kerridge{dagger}

Laboratoire de Génétique et Physiologie du Développement, UMR 9943 C.N.R.S.-Université, I.B.D.M. CNRS-INSERM-Université de la Méditerranée, Campus de Luminy Case 907, F-13288 Marseille, Cedex 09, France
* Present address: Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland

{dagger}Author for correspondence (e-mail: kerridge{at}ibdm.univ-mrs.fr)

Accepted 14 December 2001

We have carried out a genetic screen designed to isolate regulators of teashirt expression. One of these regulators is the Grunge gene, which encodes a protein with motifs found in human arginine-glutamic acid dipeptide repeat, Metastasis-associated-like and Atrophin-1 proteins. Grunge is the only Atrophin-like protein in Drosophila, whereas several exist in humans. We provide evidence that Grunge is required for the proper regulation of teashirt but also has multiple activities in fly development. First, Grunge is crucial for correct segmentation during embryogenesis via a failure in the repression of at least four segmentation genes known to regulate teashirt. Second, Grunge acts positively to regulate teashirt expression in proximoventral parts of the leg. Grunge has other regulatory functions in the leg, including the patterning of ventral parts along the entire proximodistal axis and the proper spacing of bristles in all regions.

Key words: Drosophila, Grunge, Teashirt, Legs, Atrophin-1-like proteins, Metastasis-associated proteins, Segmentation


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
R. Hou and N. E. S. Sibinga
Atrophin Proteins Interact with the Fat1 Cadherin and Regulate Migration and Orientation in Vascular Smooth Muscle Cells
J. Biol. Chem., March 13, 2009; 284(11): 6955 - 6965.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
N. Link, P. Chen, W.-J. Lu, K. Pogue, A. Chuong, M. Mata, J. Checketts, and J. M. Abrams
A collective form of cell death requires homeodomain interacting protein kinase
J. Cell Biol., August 9, 2007; 178(4): 567 - 574.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
D. M. Tyler, W. Li, N. Zhuo, B. Pellock, and N. E. Baker
Genes Affecting Cell Competition in Drosophila
Genetics, February 1, 2007; 175(2): 643 - 657.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. A. Martin and G. Morata
Compartments and the control of growth in the Drosophila wing imaginal disc
Development, November 15, 2006; 133(22): 4421 - 4426.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Matakatsu and S. S. Blair
Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins
Development, June 15, 2006; 133(12): 2315 - 2324.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Asai, D. K. Chan, C. J. Starr, J. A. Kappler, R. Kollmar, and A. J. Hudspeth
Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear
PNAS, June 13, 2006; 103(24): 9069 - 9074.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Wehn and G. Campbell
Genetic Interactions Among scribbler, Atrophin and groucho in Drosophila Uncover Links in Transcriptional Repression
Genetics, June 1, 2006; 173(2): 849 - 861.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C.-L. Zhang, Y. Zou, R. T. Yu, F. H. Gage, and R. M. Evans
Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1.
Genes & Dev., May 15, 2006; 20(10): 1308 - 1320.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
L. Wang, H. Rajan, J. L. Pitman, M. McKeown, and C.-C. Tsai
Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors
Genes & Dev., March 1, 2006; 20(5): 525 - 530.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Fujioka, R. J. Wessells, Z. Han, J. Liu, K. Fitzgerald, G. L. Yusibova, M. Zamora, P. Ruiz-Lozano, R. Bodmer, and J. B. Jaynes
Embryonic even skipped-Dependent Muscle and Heart Cell Fates Are Required for Normal Adult Activity, Heart Function, and Lifespan
Circ. Res., November 25, 2005; 97(11): 1108 - 1114.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
B. Arca, F. Lombardo, J. G. Valenzuela, I. M. B. Francischetti, O. Marinotti, M. Coluzzi, and J. M. C. Ribeiro
An updated catalogue of salivary gland transcripts in the adult female mosquito, Anopheles gambiae
J. Exp. Biol., October 15, 2005; 208(20): 3971 - 3986.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Cho and K. D. Irvine
Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
Development, September 15, 2004; 131(18): 4489 - 4500.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. W. Kankel, D. M. Duncan, and I. Duncan
A Screen for Genes That Interact With the Drosophila Pair-Rule Segmentation Gene fushi tarazu
Genetics, September 1, 2004; 168(1): 161 - 180.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. Luschnig, B. Moussian, J. Krauss, I. Desjeux, J. Perkovic, and C. Nusslein-Volhard
An F1 Genetic Screen for Maternal-Effect Mutations Affecting Embryonic Pattern Formation in Drosophila melanogaster
Genetics, May 1, 2004; 167(1): 325 - 342.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. S. Zoltewicz, N. J. Stewart, R. Leung, and A. S. Peterson
Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis
Development, January 1, 2004; 131(1): 3 - 14.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Fujioka, B. C. Lear, M. Landgraf, G. L. Yusibova, J. Zhou, K. M. Riley, N. H. Patel, and J. B. Jaynes
Even-skipped, acting as a repressor, regulates axonal projections in Drosophila
Development, November 15, 2003; 130(22): 5385 - 5400.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
Y. Okamura-Oho, T. Miyashita, K. Nagao, S. Shima, Y. Ogata, T. Katada, H. Nishina, and M. Yamada
Dentatorubral-pallidoluysian atrophy protein is phosphorylated by c-Jun NH2-terminal kinase
Hum. Mol. Genet., July 1, 2003; 12(13): 1535 - 1542.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Fanto, L. Clayton, J. Meredith, K. Hardiman, B. Charroux, S. Kerridge, and H. McNeill
The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor
Development, February 15, 2003; 130(4): 763 - 774.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2002