spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arendt, D.
Right arrow Articles by Wittbrodt, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arendt, D.
Right arrow Articles by Wittbrodt, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Development 129, 1143-1154 (2002)
© 2002 The Company of Biologists Limited

Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria

Detlev Arendt1, Kristin Tessmar1,*, Maria-Ines Medeiros de Campos-Baptista1, Adriaan Dorresteijn2 and Joachim Wittbrodt1,{dagger}

1 European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany
2 Institut fuer Allgemeine und Spezielle Zoologie, Justus-Liebig-Universität, Stephanstr. 24, 35390 Giessen, Germany
* Present address: Department of Biochemistry and Biophysics, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA

{dagger}Author for correspondence (e-mail: jochen.wittbrodt{at}embl-heidelberg.de)

Accepted 11 December 2001

The role of Pax6 in eye development in insects and vertebrates supports the view that their eyes evolved from simple pigment-cup ocelli present in their last common ancestors (Urbilateria). The cerebral eyes in errant polychaetes represent prototype invertebrate pigment-cup ocelli and thus resemble the presumed ancestral eyes. We have analysed expression of conserved eye specification genes in the early development of larval and adult pigment-cup eyes in Platynereis dumerilii (Polychaeta, Annelida, Lophotrochozoa). Both larval and adult eyes form in close vicinity of the optic anlagen on both sides of the developing brain ganglia. While pax6 is expressed in the larval, but not in the developing, adult eyes, expression of six1/2 from trochophora stages onwards specifically outlines the optic anlagen and thus covers both the developing larval and adult eyes. Using Platynereis rhabdomeric opsin as differentiation marker, we show that the first pair of adult eye photoreceptor cells is detected within bilateral clusters that transitorily express ath, the Platynereis atonal orthologue, thus resembling proneural sensory clusters. Our data indicate that – similar to insects, but different from the vertebrates – polychaete six1/2 expression outlines the entire visual system from early developmental stages onwards and ath-positive clusters generate the first photoreceptor cells to appear. We propose that pax6-, six1/2- and ath-positive larval eyes, as found in today’s trochophora, were present already in Urbilateria.

Key words: Platynereis, Eye, Evolution, Larval eyes, Adult eyes, six, pax6, Lochotrophozoa, Annelids


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Phil Trans R Soc BHome page
P. Vopalensky and Z. Kozmik
Eye evolution: common use and independent recruitment of genetic components
Phil Trans R Soc B, October 12, 2009; 364(1531): 2819 - 2832.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
A. Hejnol and M. Q Martindale
Acoel development supports a simple planula-like urbilaterian
Phil Trans R Soc B, April 27, 2008; 363(1496): 1493 - 1501.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
G. Schlosser
How old genes make a new head: redeployment of Six and Eya genes during the evolution of vertebrate cranial placodes
Integr. Comp. Biol., September 1, 2007; 47(3): 343 - 359.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
H. N. Cinar and A. D. Chisholm
Genetic Analysis of the Caenorhabditis elegans pax-6 Locus: Roles of Paired Domain-Containing and Nonpaired Domain-Containing Isoforms
Genetics, November 1, 2004; 168(3): 1307 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. Arendt, K. Tessmar-Raible, H. Snyman, A. W. Dorresteijn, and J. Wittbrodt
Ciliary Photoreceptors with a Vertebrate-Type Opsin in an Invertebrate Brain
Science, October 29, 2004; 306(5697): 869 - 871.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. Poggi, T. Vottari, G. Barsacchi, J. Wittbrodt, and R. Vignali
The homeobox gene Xbh1 cooperates with proneural genes to specify ganglion cell fate within the Xenopus neural retina
Development, May 15, 2004; 131(10): 2305 - 2315.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2002