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Development 129, 1387-1396 (2002)
© 2002 The Company of Biologists Limited

The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRß-containing receptors

Chi Vinh Duong, Markus Geissen and Hermann Rohrer*

Max-Planck-Institut für Hirnforschung, Abteilung Neurochemie, Deutschordenstr. 46, 60528 Frankfurt / Main, Germany

*Author for correspondence (e-mail: rohrer{at}mpih-frankfurt.mpg.de)

Accepted 20 December 2001

Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. Cholinergic sympathetic neurons are characterized by the expression of choline acetyl transferase (ChAT), vesicular acetylcholine transporter (VAChT) and the vasoactive intestinal peptide (VIP). To investigate the role of cytokine growth factor family members in the development of cholinergic sympathetic neurons, we interfered in vivo with the function of the subclass of cytokine receptors that contains LIFRß as essential receptor subunit. Expression of LIFRß antisense RNA interfered with LIFRß expression and strongly reduced the developmental induction of VIP expression. By contrast, ganglion size and the number of ChAT-positive cells were not reduced. These results demonstrate a physiological role of cytokines acting through LIFRß-containing receptors in the control of VIP expression in sympathetic neurons.

Key words: LIF, Cytokine, Transmitter, Plasticity, Chick, Noradrenergic, Cholinergic, VIP


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[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2002