spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Duong, C. V.
Right arrow Articles by Rohrer, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duong, C. V.
Right arrow Articles by Rohrer, H.
Development 129, 1387-1396 (2002)
© 2002 The Company of Biologists Limited

The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRß-containing receptors

Chi Vinh Duong, Markus Geissen and Hermann Rohrer*

Max-Planck-Institut für Hirnforschung, Abteilung Neurochemie, Deutschordenstr. 46, 60528 Frankfurt / Main, Germany

*Author for correspondence (e-mail: rohrer{at}mpih-frankfurt.mpg.de)

Accepted 20 December 2001

Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. Cholinergic sympathetic neurons are characterized by the expression of choline acetyl transferase (ChAT), vesicular acetylcholine transporter (VAChT) and the vasoactive intestinal peptide (VIP). To investigate the role of cytokine growth factor family members in the development of cholinergic sympathetic neurons, we interfered in vivo with the function of the subclass of cytokine receptors that contains LIFRß as essential receptor subunit. Expression of LIFRß antisense RNA interfered with LIFRß expression and strongly reduced the developmental induction of VIP expression. By contrast, ganglion size and the number of ChAT-positive cells were not reduced. These results demonstrate a physiological role of cytokines acting through LIFRß-containing receptors in the control of VIP expression in sympathetic neurons.

Key words: LIF, Cytokine, Transmitter, Plasticity, Chick, Noradrenergic, Cholinergic, VIP




This article has been cited by other articles:


Home page
 DevelopmentHome page
F. Muller and H. Rohrer
Molecular control of ciliary neuron development: BMPs and downstream transcriptional control in the parasympathetic lineage
Development, March 14, 2003; 129(24): 5707 - 5717.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2002