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Development 129, 1467-1476 (2002)
© 2002 The Company of Biologists Limited

reaper is required for neuroblast apoptosis during Drosophila development

Christian Peterson1, Ginger E. Carney2, Barbara J. Taylor2 and Kristin White1,*

1 CBRC, Massachusetts General Hospital/Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
2 Department of Zoology, Oregon State University, 3029 Cordley Hall, Corvallis, OR 97331, USA

*Author for correspondence (e-mail: kristin.white{at}cbrc2.mgh.harvard.edu)

Accepted 31 December 2001

Developmentally regulated apoptosis in Drosophila requires the activity of the reaper (rpr), grim and head involution defective (hid) genes. The expression of these genes is differentially regulated, suggesting that there are distinct requirements for their proapoptotic activity in response to diverse developmental and environmental inputs. To examine this hypothesis, a mutation that removes the rpr gene was generated. In flies that lack rpr function, most developmental apoptosis was unaffected. However, the central nervous systems of rpr null flies were very enlarged. This was due to the inappropriate survival of both larval neurons and neuroblasts. Importantly, neuroblasts rescued from apoptosis remained functional, continuing to proliferate and generating many extra neurons. Males mutant for rpr exhibited behavioral defects resulting in sterility. Although both the ecdysone hormone receptor complex and p53 directly regulate rpr transcription, rpr was found to play a limited role in inducing apoptosis in response to either of these signals.

Key words: Drosophila melanogaster, Apoptosis, reaper, p53, Neuroblast


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© The Company of Biologists Ltd 2002