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doi: 10.1242/10.1242/dev.00424

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Development 130, 2095-2105 (2003)
Copyright © 2003 The Company of Biologists Limited

Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal

Hui-Hsin Tsai1, Marc Tessier-Lavigne2 and Robert H. Miller1,*

1 Department of Neurosciences, Case Western Reserve University, School Of Medicine, Cleveland, OH 44106, USA
2 Department of Biological Sciences, Stanford University, Herrin Lab 150, 385 Serra Mall Stanford CA, 94305, USA

* Author for correspondence (e-mail: rhm3{at}po.cwru.edu)

Accepted 3 February 2003

In spinal cord, oligodendrocyte precursors that give rise to myelin-forming cells originate in a restricted domain of the ventral ventricular zone. During development, these cells migrate widely throughout the spinal cord. Netrin 1 is expressed at the ventral ventricular zone during oligodendrocyte precursors emigration, and, in vitro, netrin 1 acts as chemorepellent and antagonizes platelet-derived growth factor (PDGF) chemoattraction. Oligodendrocyte precursors express the netrin receptors DCC and UNC5 and function-blocking anti-DCC antibody inhibits chemorepulsion of ventral spinal cord explants and netrin-secreting cells. In spinal cord slice preparations, addition of function-blocking anti-DCC antibody or netrin 1 dramatically inhibits oligodendrocyte precursor migration from the ventral ventricular zone. These data indicate the initial dispersal of oligodendrocyte precursors from their localized origin is guided by a chemorepellent response to netrin 1.

Key words: Oligodendrocyte precursor, Migration, Netrin, Chick


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© The Company of Biologists Ltd 2003