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doi: 10.1242/10.1242/dev.00443

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Development 130, 2225-2238 (2003)
Copyright © 2003 The Company of Biologists Limited

Notch activates sonic hedgehog and both are involved in the specification of dorsal midline cell-fates in Xenopus

Silvia L. López, Alejandra R. Paganelli*, María V. Rosato Siri*, Oscar H. Ocaña, Paula G. Franco and Andrés E. Carrasco{dagger}

Laboratorio de Embriología Molecular, Instituto de Biología Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 3° piso (1121), Buenos Aires, Argentina

{dagger} Author for correspondence (e-mail: rqcarras{at}mail.retina.ar)

Accepted 13 February 2003

We analysed the role of Notch signalling during the specification of the dorsal midline in Xenopus embryos. By activating or blocking the pathway we found that Notch expands the floor plate domain of sonic hedgehog and pintallavis and represses the notochordal markers chordin and brachyury, with a concomitant reduction of the notochord size. We propose that within a population of the early organiser with equivalent potential to develop either as notochord or floor plate, Notch activation favours floor plate development at the expense of the notochord, preferentially before mid gastrula. We present evidence that sonic hedgehog down-regulates chordin, suggesting that secreted Sonic hedgehog may be involved or reinforcing the cell-fate switch executed by Notch. We also show that Notch signalling requires Presenilin to modulate this switch.

Key words: Notch, Sonic hedgehog, Chordin, Floor plate, Notochord, Presenilin, Xenopus laevis


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© The Company of Biologists Ltd 2003