|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
doi: 10.1242/10.1242/dev.00440
1 Département Génétique, Développement et Pathologie
Moléculaire, Institut Cochin – INSERM 567, CNRS UMR 8104,
Université Paris V, 24 Rue du Faubourg Saint Jacques, 75014 Paris,
France
2 Plateforme Recombinaison Homologue, Institut Cochin – INSERM 567, CNRS
UMR 8104, Université Paris V, 24 Rue du Faubourg Saint Jacques, 75014
Paris, France
3 Plateforme Histologie, Institut Cochin – INSERM 567, CNRS UMR 8104,
Université Paris V, 24 Rue du Faubourg Saint Jacques, 75014 Paris,
France
* Author for correspondence (e-mail: maire{at}mail.cochin.inserm.fr)
Accepted 14 February 2003
Six homeoproteins are expressed in several tissues, including muscle, during vertebrate embryogenesis, suggesting that they may be involved in diverse differentiation processes. To determine the functions of the Six1 gene during myogenesis, we constructed Six1-deficient mice by replacing its first exon with the lacZ gene. Mice lacking Six1 die at birth because of severe rib malformations and show extensive muscle hypoplasia affecting most of the body muscles in particular certain hypaxial muscles. Six1–/– embryos have impaired primary myogenesis, characterized, at E13.5, by a severe reduction and disorganisation of primary myofibers in most body muscles. While Myf5, MyoD and myogenin are correctly expressed in the somitic compartment in early Six1–/– embryos, by E11.5 MyoD and myogenin gene activation is reduced and delayed in limb buds. However, this is not the consequence of a reduced ability of myogenic precursor cells to migrate into the limb buds or of an abnormal apoptosis of myoblasts lacking Six1. It appears therefore that Six1 plays a specific role in hypaxial muscle differentiation, distinct from those of other hypaxial determinants such as Pax3, cMet, Lbx1 or Mox2.
Key words: Six/sine oculis homeoproteins, Myogenesis, MyoD, Myogenin, Myf5, Pax3
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Savage, A. J. Conley, A. Blais, and I. S. Skerjanc SOX15 and SOX7 Differentially Regulate the Myogenic Program in P19 Cells Stem Cells, June 1, 2009; 27(6): 1231 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang and E. Stavnezer Ski Regulates Muscle Terminal Differentiation by Transcriptional Activation of Myog in a Complex with Six1 and Eya3 J. Biol. Chem., January 30, 2009; 284(5): 2867 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Giordani, L. Bajard, J. Demignon, P. Daubas, M. Buckingham, and P. Maire Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs PNAS, July 3, 2007; 104(27): 11310 - 11315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhu, A. S. Gleiberman, and M. G. Rosenfeld Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks Physiol Rev, July 1, 2007; 87(3): 933 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Behbakht, L. Qamar, C. S. Aldridge, R. D. Coletta, S. A. Davidson, A. Thorburn, and H. L. Ford Six1 Overexpression in Ovarian Carcinoma Causes Resistance to TRAIL-Mediated Apoptosis and Is Associated with Poor Survival Cancer Res., April 1, 2007; 67(7): 3036 - 3042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Porter, S. Israel, B. Gong, A. P. Merriam, J. Feuerman, S. Khanna, and H. J. Kaminski Distinctive morphological and gene/protein expression signatures during myogenesis in novel cell lines from extraocular and hindlimb muscle Physiol Genomics, February 23, 2006; 24(3): 264 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yu, E. Davicioni, T. J. Triche, and G. Merlino The Homeoprotein Six1 Transcriptionally Activates Multiple Protumorigenic Genes but Requires Ezrin to Promote Metastasis Cancer Res., February 15, 2006; 66(4): 1982 - 1989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Grifone, J. Demignon, C. Houbron, E. Souil, C. Niro, M. J. Seller, G. Hamard, and P. Maire Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo Development, May 1, 2005; 132(9): 2235 - 2249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Reichenberger, R. D. Coletta, A. P. Schulte, M. Varella-Garcia, and H. L. Ford Gene Amplification Is a Mechanism of Six1 Overexpression in Breast Cancer Cancer Res., April 1, 2005; 65(7): 2668 - 2675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kutejova, B. Engist, M. Mallo, B. Kanzler, and N. Bobola Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme Development, February 1, 2005; 132(3): 469 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Silver and I. Rebay Signaling circuitries in development: insights from the retinal determination gene network Development, January 1, 2005; 132(1): 3 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V. Sampogna and S. K. Nigam Implications of Gene Networks for Understanding Resilience and Vulnerability in the Kidney Branching Program Physiology, December 1, 2004; 19(6): 339 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zou, D. Silvius, B. Fritzsch, and P.-X. Xu Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes Development, November 15, 2004; 131(22): 5561 - 5572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Borue and D. M. Noden Normal and aberrant craniofacial myogenesis by grafted trunk somitic and segmental plate mesoderm Development, August 15, 2004; 131(16): 3967 - 3980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Grifone, C. Laclef, F. Spitz, S. Lopez, J. Demignon, J.-E. Guidotti, K. Kawakami, P.-X. Xu, R. Kelly, B. J. Petrof, et al. Six1 and Eya1 Expression Can Reprogram Adult Muscle from the Slow-Twitch Phenotype into the Fast-Twitch Phenotype Mol. Cell. Biol., July 15, 2004; 24(14): 6253 - 6267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Ruf, P.-X. Xu, D. Silvius, E. A. Otto, F. Beekmann, U. T. Muerb, S. Kumar, T. J. Neuhaus, M. J. Kemper, R. M. Raymond Jr., et al. SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes PNAS, May 25, 2004; 101(21): 8090 - 8095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Coletta, K. Christensen, K. J. Reichenberger, J. Lamb, D. Micomonaco, L. Huang, D. M. Wolf, C. Muller-Tidow, T. R. Golub, K. Kawakami, et al. The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1 PNAS, April 27, 2004; 101(17): 6478 - 6483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Shah, R. V. Sampogna, H. Sakurai, K. T. Bush, and S. K. Nigam Branching morphogenesis and kidney disease Development, April 1, 2004; 131(7): 1449 - 1462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Delfini and D. Duprez Ectopic Myf5 or MyoD prevents the neuronal differentiation program in addition to inducing skeletal muscle differentiation, in the chick neural tube Development, February 15, 2004; 131(4): 713 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ozaki, K. Nakamura, J.-i. Funahashi, K. Ikeda, G. Yamada, H. Tokano, H.-o. Okamura, K. Kitamura, S. Muto, H. Kotaki, et al. Six1 controls patterning of the mouse otic vesicle Development, February 1, 2004; 131(3): 551 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Relaix, M. Polimeni, D. Rocancourt, C. Ponzetto, B. W. Schafer, and M. Buckingham The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo Genes & Dev., December 1, 2003; 17(23): 2950 - 2965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zheng, L. Huang, Z.-B. Wei, D. Silvius, B. Tang, and P.-X. Xu The role of Six1 in mammalian auditory system development Development, September 1, 2003; 130(17): 3989 - 4000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-X. Xu, W. Zheng, L. Huang, P. Maire, C. Laclef, and D. Silvius Six1 is required for the early organogenesis of mammalian kidney Development, July 15, 2003; 130(14): 3085 - 3094. [Abstract] [Full Text] [PDF]
|
|
