spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

doi: 10.1242/10.1242/dev.00474

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takeuchi, J. K.
Right arrow Articles by Ogura, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takeuchi, J. K.
Right arrow Articles by Ogura, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Development 130, 2729-2739 (2003)
Copyright © 2003 The Company of Biologists Limited

Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade

Jun K. Takeuchi*, Kazuko Koshiba-Takeuchi*, Takayuki Suzuki, Mika Kamimura, Keiko Ogura and Toshihiko Ogura{dagger}

Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara 630-0101, Japan
* Present address: Cardiovascular Research, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada

{dagger} Author for correspondence (e-mail: ogura{at}bs.aist-nara.ac.jp).

Accepted 24 February 2003

A tight loop between members of the fibroblast growth factor and the Wnt families plays a key role in the initiation of vertebrate limb development. We show for the first time that Tbx5 and Tbx4 are directly involved in this process. When dominant-negative forms of these Tbx genes were misexpressed in the chick prospective limb fields, a limbless phenotype arose with repression of both Wnt and Fgf genes By contrast, when Tbx5 and Tbx4 were misexpressed in the flank, an additional wing-like and an additional leg-like limbs were induced, respectively. This additional limb formation was accompanied by the induction of both Wnt and Fgf genes These results highlight the pivotal roles of Tbx5 and Tbx4 during limb initiation, specification of forelimb/hindlimb and evolution of tetrapod limbs, placing Tbx genes at the center of a highly conserved genetic program.

Key words: Tbx5, Tbx4, Limb initiation, Wnt, Fgf, Chick


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in Development:

Tbx4 and Tbx5: dual roles in limb development revealed

Development 2003 130: 1205. [Full Text]  

Tbx4 and Tbx5: dual roles in limb development revealed

Development 2003 130: e1205. [Full Text]  



This article has been cited by other articles:


Home page
 DevelopmentHome page
L. A. Naiche and V. E. Papaioannou
Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth
Development, January 1, 2007; 134(1): 93 - 103.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Mercader, S. Fischer, and C. J. Neumann
Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction
Development, August 1, 2006; 133(15): 2805 - 2815.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. P. Hill, M. M. Taketo, W. Birchmeier, and C. Hartmann
Multiple roles of mesenchymal {beta}-catenin during murine limb patterning
Development, April 1, 2006; 133(7): 1219 - 1229.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Lours and S. Dietrich
The dissociation of the Fgf-feedback loop controls the limbless state of the neck
Development, December 15, 2005; 132(24): 5553 - 5564.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Murakami, M. Nakagawa, E. N. Olson, and O. Nakagawa
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
PNAS, December 13, 2005; 102(50): 18034 - 18039.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. A. Stennard and R. P. Harvey
T-box transcription factors and their roles in regulatory hierarchies in the developing heart
Development, November 15, 2005; 132(22): 4897 - 4910.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. A. Stennard, M. W. Costa, D. Lai, C. Biben, M. B. Furtado, M. J. Solloway, D. J. McCulley, C. Leimena, J. I. Preis, S. L. Dunwoodie, et al.
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation
Development, May 15, 2005; 132(10): 2451 - 2462.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Rallis, J. Del Buono, and M. P. O. Logan
Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo
Development, April 15, 2005; 132(8): 1961 - 1970.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Kuijper, A. Beverdam, C. Kroon, A. Brouwer, S. Candille, G. Barsh, and F. Meijlink
Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes
Development, April 1, 2005; 132(7): 1601 - 1610.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Kida, Y. Maeda, T. Shiraishi, T. Suzuki, and T. Ogura
Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis
Development, September 1, 2004; 131(17): 4179 - 4187.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. O. Bush, Y. Lan, and R. Jiang
The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene
PNAS, May 4, 2004; 101(18): 7022 - 7027.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Logan
Finger or toe: the molecular basis of limb identity
Development, December 29, 2003; 130(26): 6401 - 6410.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2003