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doi: 10.1242/10.1242/dev.00534

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Mechanism of hedgehog signaling during Drosophila eye development

¹ Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
² Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
³ Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
⁴ Biomedical Initiatives, University-wide AIDS Research Program, University of California Office of the President, 300 Lakeside Drive, 6th Floor, Oakland, CA 94612, USA
⁵ Department of Anatomy, University of California San Francisco, Box 0452, 513 Parnassus, San Francisco, CA 94143-0452, USA
⁶ Department of Ophthalmology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
⁷ Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA

^* Author for correspondence (e-mail: gmardon{at}bcm.tmc.edu)

Accepted 27 March 2003

Although Hedgehog (Hh) signaling is essential for morphogenesis of the Drosophila eye, its exact link to the network of tissue-specific genes that regulate retinal determination has remained elusive. In this report, we demonstrate that the retinal determination gene eyes absent (eya) is the crucial link between the Hedgehog signaling pathway and photoreceptor differentiation. Specifically, we show that the mechanism by which Hh signaling controls initiation of photoreceptor differentiation is to alleviate repression of eya and decapentaplegic (dpp) expression by the zinc-finger transcription factor Cubitus interruptus (Ci^rep). Furthermore, our results suggest that stabilized, full length Ci (Ci^act) plays little or no role in Drosophila eye development. Moreover, while the effects of Hh are primarily concentration dependent in other tissues, hh signaling in the eye acts as a binary switch to initiate retinal morphogenesis by inducing expression of the tissue-specific factor Eya.

Key words: eyes absent, hedgehog, Drosophila, Retinal determination, cubitus interruptus, Photoreceptor, Morphogenetic furrow

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