|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online August 4, 2003
doi: 10.1242/10.1242/dev.00650
Division of Developmental Biology, Children's Hospital, Cincinnati, OH 45229, USA
* Author for correspondence (e-mail: wylv9m{at}chmcc.org)
Accepted 15 April 2003
GP130 is the shared receptor for members of the IL6 family of cytokines. Members of this family have been shown to enhance the survival of migratory (E10.5) or postmigratory (E12.5) murine primordial germ cells (PGCs) in culture; however, it is uncertain what role these cytokines play during PGC development in vivo. We have examined PGC numbers in E13.5 GP130-deficient mouse embryos and found that males exhibited a slight decrease in PGC numbers; females were normal. Also, we used the Cre-loxP system to inactive GP130 specifically in germ cells and found that this resulted in a fertility defect in females. These animals were found to have a slight reduction in the number of primary follicles and a major defect in ovulation. This data suggests that GP130 is required in female germ cells for their normal function, but is dispensable in male germ cells.
Key words: GP130, LIF, Germ cells, Oogenesis, Ovulation, Mouse
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. A. Edson, A. K. Nagaraja, and M. M. Matzuk The Mammalian Ovary from Genesis to Revelation Endocr. Rev., October 1, 2009; 30(6): 624 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Liu, D. G. de Matos, H.-Y. Fan, M. Shimada, S. Palmer, and J. S. Richards Interleukin-6: An Autocrine Regulator of the Mouse Cumulus Cell-Oocyte Complex Expansion Process Endocrinology, July 1, 2009; 150(7): 3360 - 3368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Heaney, M. V. Michelson, K. K. Youngren, M.-Y. J. Lam, and J. H. Nadeau Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice Hum. Mol. Genet., April 15, 2009; 18(8): 1395 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kocer, J. Reichmann, D. Best, and I. R. Adams Germ cell sex determination in mammals Mol. Hum. Reprod., April 1, 2009; 15(4): 205 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-Y. Sun, K. Liu, and K. Kikuchi Oocyte-Specific Knockout: A Novel In Vivo Approach for Studying Gene Functions During Folliculogenesis, Oocyte Maturation, Fertilization, and Embryogenesis Biol Reprod, December 1, 2008; 79(6): 1014 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Childs, P. T.K. Saunders, and R. A. Anderson Modelling germ cell development in vitro Mol. Hum. Reprod., September 1, 2008; 14(9): 501 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kida, M. L. Mucenski, A. R. Thitoff, T. D. Le Cras, K.-S. Park, M. Ikegami, W. Muller, and J. A. Whitsett GP130-STAT3 Regulates Epithelial Cell Migration and Is Required for Repair of the Bronchiolar Epithelium Am. J. Pathol., June 1, 2008; 172(6): 1542 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shimada, Y. Yanai, T. Okazaki, Y. Yamashita, V. Sriraman, M. C. Wilson, and J. S. Richards Synaptosomal-Associated Protein 25 Gene Expression Is Hormonally Regulated during Ovulation and Is Involved in Cytokine/Chemokine Exocytosis from Granulosa Cells Mol. Endocrinol., October 1, 2007; 21(10): 2487 - 2502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.R. Barnett, C. Schilling, C.R. Greenfeld, D. Tomic, and J.A. Flaws Ovarian follicle development and transgenic mouse models Hum. Reprod. Update, September 1, 2006; 12(5): 537 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-M. Cai, Y.-T. Gui, X. Guo, J. Yu, L.-D. Guo, L.-B. Zhang, H. Wang, and J. Yu Low Expression of Glycoprotein Subunit 130 in Ejaculated Spermatozoa from Asthenozoospermic Men J Androl, September 1, 2006; 27(5): 645 - 652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. DiNapoli, J. Batchvarov, and B. Capel FGF9 promotes survival of germ cells in the fetal testis Development, April 15, 2006; 133(8): 1519 - 1527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Roy and M. M Matzuk Deconstructing mammalian reproduction: using knockouts to define fertility pathways Reproduction, February 1, 2006; 131(2): 207 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Dorval-Coiffec, J.-G. Delcros, H. Hakovirta, J. Toppari, B. Jegou, and C. Piquet-Pellorce Identification of the Leukemia Inhibitory Factor Cell Targets Within the Rat Testis Biol Reprod, March 1, 2005; 72(3): 602 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. De Felici, M.L. Scaldaferri, M. Lobascio, S. Iona, V. Nazzicone, F.G. Klinger, and D. Farini Experimental approaches to the study of primordial germ cell lineage and proliferation Hum. Reprod. Update, May 1, 2004; 10(3): 197 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Abir, B. Fisch, S. Jin, M. Barnnet, S. Freimann, R. Van den Hurk, D. Feldberg, S. Nitke, H. Krissi, and A. Ao Immunocytochemical detection and RT-PCR expression of leukaemia inhibitory factor and its receptor in human fetal and adult ovaries Mol. Hum. Reprod., May 1, 2004; 10(5): 313 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Stallock, K. Molyneaux, K. Schaible, C. M. Knudson, and C. Wylie The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo Development, December 29, 2003; 130(26): 6589 - 6597. [Abstract] [Full Text] [PDF]
|
|
