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First published online August 4, 2003
doi: 10.1242/10.1242/dev.00632
1 Departments of Pediatrics, Indiana University School of Medicine,
Indianapolis, IN 46202, USA
2 Biochemistry and Molecular Biology, Indiana University School of Medicine,
Indianapolis, IN 46202, USA
3 Herman B. Wells Center for Pediatric Research, Indiana University School of
Medicine, Indianapolis, IN 46202, USA
* Author for correspondence (e-mail:myoder{at}iupui.edu)
Accepted 28 May 2003
The platelet glycoprotein IIb (
IIb; CD41) constitutes the
alpha subunit of a highly expressed platelet surface integrin protein. We
demonstrate that CD41 serves as the earliest marker of primitive erythroid
progenitor cells in the embryonic day 7 (E7.0) yolk sac and high-level
expression identifies essentially all E8.25 yolk sac definitive hematopoietic
progenitors. Some definitive hematopoietic progenitor cells in the fetal liver
and bone marrow also express CD41. Hematopoietic stem cell competitive
repopulating ability is present in CD41dim and CD41lo/-
cells isolated from bone marrow and fetal liver cells, however, activity is
enriched in the CD41lo/- cells. CD41bright yolk sac
definitive progenitor cells co-express CD61 and bind fibrinogen, demonstrating
receptor function. Thus, CD41 expression marks the onset of primitive and
definitive hematopoiesis in the murine embryo and persists as a marker of some
stem and progenitor cell populations in the fetal liver and adult marrow,
suggesting novel roles for this integrin.
Key words: Hematopoiesis, Embryonic yolk sac, CD41, Mouse
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