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First published online August 18, 2003
doi: 10.1242/10.1242/dev.00680

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Development 130, 4683-4693 (2003)
Copyright © 2003 The Company of Biologists Limited

The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation

Petra I. zur Lage, David R. A. Prentice, Eimear E. Holohan and Andrew P. Jarman*

The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, UK

* Author for correspondence (e-mail: andrew.jarman{at}ed.ac.uk)

Accepted 20 June 2003

Proneural genes encode basic-helix-loop-helix (bHLH) transcription factors required for neural precursor specification. Recently amos was identified as a new candidate Drosophila proneural gene related to atonal. Having isolated the first specific amos loss-of-function mutations, we show definitively that amos is required to specify the precursors of two classes of olfactory sensilla. Unlike other known proneural mutations, a novel characteristic of amos loss of function is the appearance of ectopic sensory bristles in addition to loss of olfactory sensilla, owing to the inappropriate function of scute. This supports a model of inhibitory interactions between proneural genes, whereby ato-like genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ subtypes.

Key words: Proneural, bHLH, Drosophila, amos, Neurogenesis, Gene regulation


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© The Company of Biologists Ltd 2003