|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online August 18, 2003
doi: 10.1242/10.1242/dev.00666
RESEARCH ARTICLES: DEVELOPMENT AND DISEASE |
1 Department of Cell Biology, Japanese Foundation for Cancer Research (JFCR)
Cancer Institute, 1-37-1 Kami-Ikebukuro, Toshima-Ku, Tokyo 170-8455,
Japan
2 Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku
University School of Medicine, Sendai 980-8574, Japan
3 Miyagi Insurance Hospital, Sendai 981-1103, Japan
4 Laboratory for Cell Culture Development, Brain Science Institute, RIKEN, Wako,
Saitama 351-0198, Japan
5 Mouse Functional Genomics Research Group, RIKEN Genomic Sciences Center,
Kanagawa 244-0804, Japan
6 Division of Molecular Genetics, Center for Translational and Advanced Animal
Researches on Human Diseases, Tohoku University School of Medicine, Sendai
980-8575, Japan
* Author for correspondence (e-mail: tnoda{at}ims.u-tokyo.ac.jp)
Accepted 12 June 2003
This study identifies a role for the gene for the POU transcription factor Brn1 in distal tubule formation and function in the mammalian kidney. Normal development of Henle's loop (HL), the distal convoluted tubule and the macula densa was severely retarded in Brn1-deficient mice. In particular, elongation and differentiation of the developing HL was affected. In the adult kidney, Brn1 was detected only in the thick ascending limb (TAL) of HL. In addition, the expression of a number of TAL-specific genes was reduced in the Brn1+/- kidney, including Umod, Nkcc2/Slc12a1, Bsnd, Kcnj1 and Ptger3. These results suggest that Brn1 is essential for both the development and function of the nephron in the kidney.
Key words: Brn1, Henle's loop, Kidney, Distal tubule formation, POU transcription factor
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Turgeon and S. Meloche Interpreting Neonatal Lethal Phenotypes in Mouse Mutants: Insights Into Gene Function and Human Diseases Physiol Rev, January 1, 2009; 89(1): 1 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yu, T. J. Carroll, J. Rajagopal, A. Kobayashi, Q. Ren, and A. P. McMahon A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney Development, January 1, 2009; 136(1): 161 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. El-Dahr, K. Aboudehen, and Z. Saifudeen Transcriptional control of terminal nephron differentiation Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1273 - F1278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Jacquillet, O. Barbier, I. Rubera, M. Tauc, A. Borderie, M. C. Namorado, D. Martin, G. Sierra, J. L. Reyes, P. Poujeol, et al. Cadmium causes delayed effects on renal function in the offspring of cadmium-contaminated pregnant female rats Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1450 - F1460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Mah, K. R. Armstrong, D. S. Chew, J. S. Chu, D. K. Tu, R. C. Johnsen, N. Chen, H. M. Chamberlin, and D. L. Baillie Transcriptional Regulation of AQP-8, a Caenorhabditis elegans Aquaporin Exclusively Expressed in the Excretory System, by the POU Homeobox Transcription Factor CEH-6 J. Biol. Chem., September 21, 2007; 282(38): 28074 - 28086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Reggiani, D. Raciti, R. Airik, A. Kispert, and A. W. Brandli The prepattern transcription factor Irx3 directs nephron segment identity Genes & Dev., September 15, 2007; 21(18): 2358 - 2370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kopan, H.-T. Cheng, and K. Surendran Molecular Insights into Segmentation along the Proximal Distal Axis of the Nephron J. Am. Soc. Nephrol., July 1, 2007; 18(7): 2014 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Narlis, D. Grote, Y. Gaitan, S. K. Boualia, and M. Bouchard Pax2 and Pax8 Regulate Branching Morphogenesis and Nephron Differentiation in the Developing Kidney J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1121 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-T. Cheng, M. Kim, M. T. Valerius, K. Surendran, K. Schuster-Gossler, A. Gossler, A. P. McMahon, and R. Kopan Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron Development, February 15, 2007; 134(4): 801 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamaguchi, S. Yonemura, and S. Takada Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse Development, December 1, 2006; 133(23): 4737 - 4748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fan, J. Stefkova, and S. S. El-Dahr Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway Am J Physiol Renal Physiol, September 1, 2006; 291(3): F670 - F682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Grieshammer, C. Cebrian, R. Ilagan, E. Meyers, D. Herzlinger, and G. R. Martin FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons Development, September 1, 2005; 132(17): 3847 - 3857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kobayashi, K.-M. Kwan, T. J. Carroll, A. P. McMahon, C. L. Mendelsohn, and R. R. Behringer Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development Development, June 15, 2005; 132(12): 2809 - 2823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bouchard, D. Grote, S. E. Craven, Q. Sun, P. Steinlein, and M. Busslinger Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region Development, June 1, 2005; 132(11): 2633 - 2643. [Abstract] [Full Text] [PDF]
|
|
