QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

doi: 10.1242/10.1242/dev.00214

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gorfinkiel, N. Articles by Guerrero, I. Search for Related Content PubMed PubMed Citation Articles by Gorfinkiel, N. Articles by Guerrero, I.

Development of the Drosophila genital disc requires interactions between its segmental primordia

¹ Centro de Biologia Molecular `Severo Ochoa', C.S.I.C., Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid, Spain
² Centro de Investigaciones Biológicas, C.S.I.C., Velázquez 144, 28006 Madrid, Spain

^* Author for correspondence (e-mail: iguerrero{at}cbm.uam.es)

Accepted 18 October 2002

In both sexes, the Drosophila genital disc comprises three segmental primordia: the female genital primordium derived from segment A8, the male genital primordium derived from segment A9 and the anal primordium derived from segments A10-11. Each segmental primordium has an anterior (A) and a posterior (P) compartment, the P cells of the three segments being contiguous at the lateral edges of the disc. We show that Hedgehog (Hh) expressed in the P compartment differentially signals A cells at the AP compartment border and A cells at the segmental border. As in the wing imaginal disc, cell lineage restriction of the AP compartment border is defined by Hh signalling. There is also a lineage restriction barrier at the segmental borders, even though the P compartment cells of the three segments converge in the lateral areas of the disc. Lineage restriction between segments A9 and A10-11 depends on factors other than the Hh, En and Hox genes. The segmental borders, however, can be permeable to some morphogenetic signals. Furthermore, cell ablation experiments show that the presence of all primordia (either the anal or the genital primordium) during development are required for normal development of genital disc. Collectively, these findings suggest that interaction between segmental primordia is required for the normal development of the genital disc.

Key words: Drosophila genital disc patterning, Hh signalling, Dpp signalling, Wg signalling, Segmental boundaries, Cell lineage restriction

This article has been cited by other articles:

				D. Foronda, B. Estrada, L. de Navas, and E. Sanchez-Herrero Requirement of abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule Development, January 1, 2006; 133(1): 117 - 127. [Abstract] [Full Text] [PDF]