spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

doi: 10.1242/10.1242/dev.00222

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gutiérrez, L.
Right arrow Articles by Vázquez, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gutiérrez, L.
Right arrow Articles by Vázquez, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Development 130, 343-354 (2003)
Copyright © 2003 The Company of Biologists Limited

The Drosophila trithorax group gene tonalli(tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein

Luis Gutiérrez1, Mario Zurita1, James A. Kennison2 and Martha Vázquez1,*

1 Departamento de Fisiología Molecular y Genética del Desarrollo, Instituto de Biotecnología, UNAM, Cuernavaca, Morelos 62250, México
2 Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA

* Author for correspondence (e-mail: mvazquez{at}ibt.unam.mx)

Accepted 21 October 2002

The trithorax group genes are required for positive regulation of homeotic gene function. The trithorax group gene brahma encodes a SWI2/SNF2 family ATPase that is a catalytic subunit of the Brm chromatin-remodeling complex. We identified the tonalli (tna) gene in Drosophila by genetic interactions with brahma. tna mutations suppress Polycomb phenotypes and tna is required for the proper expressions of the Antennapedia, Ultrabithorax and Sex combs reduced homeotic genes. The tna gene encodes at least two proteins, a large isoform (TnaA) and a short isoform (TnaB). The TnaA protein has an SP-RING Zn finger, conserved in proteins from organisms ranging from yeast to human and thought to be involved in the sumoylation of protein substrates. Besides the SP-RING finger, the TnaA protein also has extended homology with other eukaryotic proteins, including human proteins. We show that tna mutations also interact with mutations in additional subunits of the Brm complex, with mutations in subunits of the Mediator complex, and with mutations of the SWI2/SNF2 family ATPase gene kismet. We propose that Tna is involved in postranslational modification of transcription complexes.

Key words: Homeotic gene regulation, brahma, Trithorax group, Sumoylation, Chromatin remodeling, SWI/SNF, taranis, tonalli, Drosophila melanogaster


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
M. Vazquez, M. T. Cooper, M. Zurita, and J. A. Kennison
{gamma}Tub23C Interacts Genetically With Brahma Chromatin-Remodeling Complexes in Drosophila melanogaster
Genetics, October 1, 2008; 180(2): 835 - 843.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
U. Yazdani, Z. Huang, and J. R. Terman
The Glucose Transporter (GLUT4) Enhancer Factor Is Required for Normal Wing Positioning in Drosophila
Genetics, February 1, 2008; 178(2): 919 - 929.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Beliakoff, J. Lee, H. Ueno, A. Aiyer, I. L. Weissman, G. S. Barsh, R. D. Cardiff, and Z. Sun
The PIAS-Like Protein Zimp10 Is Essential for Embryonic Viability and Proper Vascular Development
Mol. Cell. Biol., January 1, 2008; 28(1): 282 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Lee, J. Beliakoff, and Z. Sun
The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor
Nucleic Acids Res., July 26, 2007; 35(13): 4523 - 4534.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Li, G. Thyssen, J. Beliakoff, and Z. Sun
The Novel PIAS-like Protein hZimp10 Enhances Smad Transcriptional Activity
J. Biol. Chem., August 18, 2006; 281(33): 23748 - 23756.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C.-Y. Huang, J. Beliakoff, X. Li, J. Lee, X. Li, M. Sharma, B. Lim, and Z. Sun
hZimp7, a Novel PIAS-Like Protein, Enhances Androgen Receptor-Mediated Transcription and Interacts with SWI/SNF-Like BAF Complexes
Mol. Endocrinol., December 1, 2005; 19(12): 2915 - 2929.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
F. Janody, J. D. Lee, N. Jahren, D. J. Hazelett, A. Benlali, G. I. Miura, I. Draskovic, and J. E. Treisman
A Mosaic Genetic Screen Reveals Distinct Roles for trithorax and Polycomb Group Genes in Drosophila Eye Development
Genetics, January 1, 2004; 166(1): 187 - 200.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Janody, Z. Martirosyan, A. Benlali, and J. E. Treisman
Two subunits of the Drosophila mediator complex act together to control cell affinity
Development, August 15, 2003; 130(16): 3691 - 3701.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2003