|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online September 2, 2003
doi: 10.1242/10.1242/dev.00721
REVIEW |
Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
* Author for correspondence (e-mail: psoriano{at}fhcrc.org)
SUMMARY
Recent advances in genetic manipulation have greatly expanded our understanding of cellular responses to platelet-derived growth factors (PDGFs) during animal development. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialized mesenchymal and migratory cell types, both during development and in the adult animal. Furthermore, the availability of genomic sequence data has facilitated the identification of novel PDGF and PDGF receptor (PDGFR) family members in C. elegans, Drosophila, Xenopus, zebrafish and mouse. Early data from these different systems suggest that some functions of PDGFs have been evolutionarily conserved.
This article has been cited by other articles:
|
|
 |
|
  X. Yang, H. Chrisman, and C. J. Weijer PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression Development, November 1, 2008; 135(21): 3521 - 3530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Venkatesan, N. Ghosh-Choudhury, F. Das, L. Mahimainathan, A. Kamat, B. S. Kasinath, H. E. Abboud, and G. G. Choudhury Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B FASEB J, October 1, 2008; 22(10): 3469 - 3482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Plusa, A. Piliszek, S. Frankenberg, J. Artus, and A.-K. Hadjantonakis Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst Development, September 15, 2008; 135(18): 3081 - 3091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nakamura, F. Tanaka, Y. Yoshikawa, K. Mimori, H. Inoue, K. Yanaga, and M. Mori PDGF-BB is a Novel Prognostic Factor in Colorectal Cancer Ann. Surg. Oncol., August 1, 2008; 15(8): 2129 - 2136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. De Donatis, G. Comito, F. Buricchi, M. C. Vinci, A. Parenti, A. Caselli, G. Camici, G. Manao, G. Ramponi, and P. Cirri Proliferation Versus Migration in Platelet-derived Growth Factor Signaling: THE KEY ROLE OF ENDOCYTOSIS J. Biol. Chem., July 18, 2008; 283(29): 19948 - 19956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Andrae, R. Gallini, and C. Betsholtz Role of platelet-derived growth factors in physiology and medicine Genes & Dev., May 15, 2008; 22(10): 1276 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. McCabe and M. Bronner-Fraser Essential role for PDGF signaling in ophthalmic trigeminal placode induction Development, May 15, 2008; 135(10): 1863 - 1874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Finzsch, C. C. Stolt, P. Lommes, and M. Wegner Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor {alpha} expression Development, February 15, 2008; 135(4): 637 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Pickett, G. S. Olsen, and M. D. Tallquist Disruption of PDGFR{alpha}-initiated PI3K activation and migration of somite derivatives leads to spina bifida Development, February 1, 2008; 135(3): 589 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Reddi, G. Ying, L. Duan, G. Chen, M. Dimri, P. Douillard, B. J. Druker, M. Naramura, V. Band, and H. Band Binding of Cbl to a Phospholipase C{gamma}1-docking Site on Platelet-derived Growth Factor Receptor beta Provides a Dual Mechanism of Negative Regulation J. Biol. Chem., October 5, 2007; 282(40): 29336 - 29347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Gilbert, G. Bender, E. Betters, M. Yin, and J. A. Cebra-Thomas The contribution of neural crest cells to the nuchal bone and plastron of the turtle shell Integr. Comp. Biol., September 1, 2007; 47(3): 401 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tozer, M.-A. Bonnin, F. Relaix, S. Di Savino, P. Garcia-Villalba, P. Coumailleau, and D. Duprez Involvement of vessels and PDGFB in muscle splitting during chick limb development Development, July 15, 2007; 134(14): 2579 - 2591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Yang, C. Lin, S. Zhao, H. Wang, and Z.-R. Liu Phosphorylation of p68 RNA Helicase Plays a Role in Platelet-derived Growth Factor-induced Cell Proliferation by Up-regulating Cyclin D1 and c-Myc Expression J. Biol. Chem., June 8, 2007; 282(23): 16811 - 16819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. S. Rajkumar, X. Shiwen, M. Bostrom, P. Leoni, J. Muddle, M. Ivarsson, B. Gerdin, C. P. Denton, G. Bou-Gharios, C. M. Black, et al. Platelet-Derived Growth Factor-{beta} Receptor Activation Is Essential for Fibroblast and Pericyte Recruitment during Cutaneous Wound Healing Am. J. Pathol., December 1, 2006; 169(6): 2254 - 2265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Dewachter, S. Adnot, E. Fadel, M. Humbert, B. Maitre, A.-M. Barlier-Mur, G. Simonneau, M. Hamon, R. Naeije, and S. Eddahibi Angiopoietin/Tie2 Pathway Influences Smooth Muscle Hyperplasia in Idiopathic Pulmonary Hypertension Am. J. Respir. Crit. Care Med., November 1, 2006; 174(9): 1025 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. Nystrom, P. Lindblom, A. Wickman, I. Andersson, J. Norlin, J. Faldt, P. Lindahl, O. Skott, M. Bjarnegard, S. M. Fitzgerald, et al. Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries Cardiovasc Res, August 1, 2006; 71(3): 557 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yamada, Y. Ozawa, M. Tomoeda, R. Matoba, K. Matsubara, and S. Murakami Regulation of PLAP-1 Expression in Periodontal Ligament Cells. J. Dent. Res., May 1, 2006; 85(5): 447 - 451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Chen, J. Aravindakshan, Y. Yang, R. Tiwari-Pandey, and M.R. Sairam Aberrant expression of PDGF ligands and receptors in the tumor prone ovary of follitropin receptor knockout (FORKO) mouse Carcinogenesis, May 1, 2006; 27(5): 903 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Tejada, L. Yu, J. Dong, K. Jung, G. Meng, F. V. Peale, G. D. Frantz, L. Hall, X. Liang, H.-P. Gerber, et al. Tumor-Driven Paracrine Platelet-Derived Growth Factor Receptor {alpha} Signaling Is a Key Determinant of Stromal Cell Recruitment in a Model of Human Lung Carcinoma. Clin. Cancer Res., May 1, 2006; 12(9): 2676 - 2688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Adams Nerve Cell Signposts in the Blood Vessel Roadmap Circ. Res., March 3, 2006; 98(4): 440 - 442. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Faraone, M. S. Aguzzi, G. Ragone, K. Russo, M. C. Capogrossi, and A. Facchiano Heterodimerization of FGF-receptor 1 and PDGF-receptor-{alpha}: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells Blood, March 1, 2006; 107(5): 1896 - 1902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tarsitano, S. De Falco, V. Colonna, J. D. McGhee, and M. G. Persico The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis FASEB J, February 1, 2006; 20(2): 227 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Narita, A. Usui, M. Narita, K. Niikura, H. Nozaki, J. Khotib, Y. Nagumo, Y. Yajima, and T. Suzuki Protease-Activated Receptor-1 and Platelet-Derived Growth Factor in Spinal Cord Neurons Are Implicated in Neuropathic Pain after Nerve Injury J. Neurosci., October 26, 2005; 25(43): 10000 - 10009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Armulik, A. Abramsson, and C. Betsholtz Endothelial/Pericyte Interactions Circ. Res., September 16, 2005; 97(6): 512 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Van Stry, A. Kazlauskas, S. L. Schreiber, and K. Symes Distinct effectors of platelet-derived growth factor receptor-{alpha} signaling are required for cell survival during embryogenesis PNAS, June 7, 2005; 102(23): 8233 - 8238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lehti, E. Allen, H. Birkedal-Hansen, K. Holmbeck, Y. Miyake, T.-H. Chun, and S. J. Weiss An MT1-MMP-PDGF receptor-{beta} axis regulates mural cell investment of the microvasculature Genes & Dev., April 15, 2005; 19(8): 979 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A G Kayali, A Stotland, K V Gunst, M Kritzik, G Liu, S Dabernat, Y-Q Zhang, W Wu, and N Sarvetnick Growth factor-induced signaling of the pancreatic epithelium J. Endocrinol., April 1, 2005; 185(1): 45 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Li, Y. Li, W. Du, L. Zhang, S. Yu, Y. Dai, C. Zhao, and N. Li Aberrant Gene Expression in Organs of Bovine Clones That Die Within Two Days after Birth Biol Reprod, February 1, 2005; 72(2): 258 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Cupedo and R. E. Mebius Cellular Interactions in Lymph Node Development J. Immunol., January 1, 2005; 174(1): 21 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Davidoff, R. Middendorff, G. Enikolopov, D. Riethmacher, A. F. Holstein, and D. Muller Progenitor cells of the testosterone-producing Leydig cells revealed J. Cell Biol., December 6, 2004; 167(5): 935 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Trentin, C. Glavieux-Pardanaud, N. M. Le Douarin, and E. Dupin Self-renewal capacity is a widespread property of various types of neural crest precursor cells PNAS, March 30, 2004; 101(13): 4495 - 4500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. G. Kaelin Jr. Gleevec: Prototype or Outlier? Sci. Signal., March 23, 2004; 2004(225): pe12 - pe12. [Abstract] [Full Text] [PDF]
|
|
