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First published online 3 September 2003
doi: 10.1242/dev.00732

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Maternal macho-1 is an intrinsic factor that makes cell response to the same FGF signal differ between mesenchyme and notochord induction in ascidian embryos

Kenji Kobayashi^1,*,, Kaichiro Sawada¹, Hiroki Yamamoto¹, Shuichi Wada^2,*, Hidetoshi Saiga² and Hiroki Nishida¹

¹ Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 226-8501, Japan
² Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minamiohsawa, Hachiohji, Tokyo 192-0397, Japan

Author for correspondence (e-mail: kobaken{at}ascidian.zool.kyoto-u.ac.jp)

Accepted 14 July 2003

An extracellular signaling molecule acts on several types of cells, evoking characteristic and different responses depending on intrinsic factors in the signal-receiving cells. In ascidian embryos, notochord and mesenchyme are induced in the anterior and posterior margins, respectively, of the vegetal hemisphere by the same FGF signal emanating from endoderm precursors. The difference in the responsiveness depends on the inheritance of the posterior-vegetal egg cytoplasm. We show that macho-1, first identified as a localized muscle determinant, is also required for mesenchyme induction, and that it plays a role in making the cell response differ between notochord and mesenchyme induction. A zygotic event involving snail expression downstream of maternal macho-1 mediates the suppression of notochord induction in mesenchyme precursors.

Key words: Mesenchyme, Notochord, Induction, Responsiveness, Intrinsic factor, macho-1, FGF, snail, Ascidian

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