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First published online 24 September 2003
doi: 10.1242/dev.00760

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Development 130, 5445-5455 (2003)
Copyright © 2003 The Company of Biologists Limited

Tgfß signaling acts on a Hox response element to confer specificity and diversity to Hox protein function

Aurélie Grienenberger1, Samir Merabet1,*, John Manak2,3, Isabelle Iltis1, Aurélie Fabre1, Hélène Bérenger1, Matthew P. Scott2,3, Jacques Pradel1 and Yacine Graba1,{dagger}

1 Laboratoire de Génétique et Biologie du Développement, IBDM, CNRS, Université de la méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France
2 Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5427, USA
3 Department of Genetics, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5427, USA

{dagger} Author for correspondence (e-mail: graba{at}lgpd.univ-mrs.fr)

Accepted 29 July 2003

Hox proteins play fundamental roles in generating pattern diversity during development and evolution, acting in broad domains but controlling localized cell diversification and pattern. Much remains to be learned about how Hox selector proteins generate cell-type diversity. In this study, regulatory specificity was investigated by dissecting the genetic and molecular requirements that allow the Hox protein Abdominal A to activate wingless in only a few cells of its broad expression domain in the Drosophila visceral mesoderm. We show that the Dpp/Tgfß signal controls Abdominal A function, and that Hox protein and signal-activated regulators converge on a wingless enhancer. The signal, acting through Mad and Creb, provides spatial information that subdivides the domain of Abdominal A function through direct combinatorial action, conferring specificity and diversity upon Abdominal A activity.

Key words: Hox, Signaling, Drosophila, AbdA, Dpp/Tgfß


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