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First published online 24 September 2003
doi: 10.1242/dev.00760

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: dev.00760v1 130/22/5445    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Grienenberger, A. Articles by Graba, Y. Search for Related Content PubMed PubMed Citation Articles by Grienenberger, A. Articles by Graba, Y.

Tgfß signaling acts on a Hox response element to confer specificity and diversity to Hox protein function

Aurélie Grienenberger¹, Samir Merabet^1,*, John Manak^2,3, Isabelle Iltis¹, Aurélie Fabre¹, Hélène Bérenger¹, Matthew P. Scott^2,3, Jacques Pradel¹ and Yacine Graba^1,

¹ Laboratoire de Génétique et Biologie du Développement, IBDM, CNRS, Université de la méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France
² Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5427, USA
³ Department of Genetics, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5427, USA

Author for correspondence (e-mail: graba{at}lgpd.univ-mrs.fr)

Accepted 29 July 2003

Hox proteins play fundamental roles in generating pattern diversity during development and evolution, acting in broad domains but controlling localized cell diversification and pattern. Much remains to be learned about how Hox selector proteins generate cell-type diversity. In this study, regulatory specificity was investigated by dissecting the genetic and molecular requirements that allow the Hox protein Abdominal A to activate wingless in only a few cells of its broad expression domain in the Drosophila visceral mesoderm. We show that the Dpp/Tgfß signal controls Abdominal A function, and that Hox protein and signal-activated regulators converge on a wingless enhancer. The signal, acting through Mad and Creb, provides spatial information that subdivides the domain of Abdominal A function through direct combinatorial action, conferring specificity and diversity upon Abdominal A activity.

Key words: Hox, Signaling, Drosophila, AbdA, Dpp/Tgfß

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Divide and rule: combinatory control of Hox domains

Development 2003 130: 2205. [Full Text]  

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