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First published online 1 October 2003
doi: 10.1242/dev.00762

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Development 130, 5569-5578 (2003)
Copyright © 2003 The Company of Biologists Limited

PP2A:B56{epsilon} is required for Wnt/ß-catenin signaling during embryonic development

Jing Yang, Jinling Wu, Change Tan and Peter S. Klein*

Department of Medicine (Hematology-Oncology) and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 364 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA

* Author for correspondence (e-mail: pklein{at}mail.med.upenn.edu)

Accepted 29 July 2003

The Wnt/ß-catenin pathway plays important roles during embryonic development and growth control. The B56 regulatory subunit of protein phosphatase 2A (PP2A) has been implicated as a regulator of this pathway. However, this has not been investigated by loss-of-function analyses. Here we report loss-of-function analysis of PP2A:B56{epsilon} during early Xenopus embryogenesis. We provide direct evidence that PP2A:B56{epsilon} is required for Wnt/ß-catenin signaling upstream of Dishevelled and downstream of the Wnt ligand. We show that maternal PP2A:B56{epsilon} function is required for dorsal development, and PP2A:B56{epsilon} function is required later for the expression of the Wnt target gene engrailed, for subsequent midbrain-hindbrain boundary formation, and for closure of the neural tube. These data demonstrate a positive role for PP2A:B56{epsilon} in the Wnt pathway.

Key words: Wnt/ß-catenin, Protein phosphatase 2A, B56, Xenopus, Embryo




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