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First published online 1 October 2003
doi: 10.1242/dev.00810

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The RNA-binding protein Vg1 RBP is required for cell migration during early neural development

¹ Department of Anatomy and Cell Biology, Hebrew University – Hadassah Medical School, POB 12272, 91120 Jerusalem, Israel
² Department of Cellular Biochemistry and Human Genetics, Hebrew University – Hadassah Medical School, POB 12272, 91120 Jerusalem, Israel

^* Author for correspondence (e-mail: yisraeli{at}cc.huji.ac.il)

Accepted 6 August 2003

After mid-blastula transition, populations of cells within the Xenopus embryo become motile. Using antisense morpholino oligonucleotides, we find that Vg1 RBP, an RNA-binding protein implicated in RNA localization in oocytes, is required for the migration of cells forming the roof plate of the neural tube and, subsequently, for neural crest migration. These cells are properly determined but remain at their site of origin. Consistent with a possible role in cell movement, Vg1 RBP asymmetrically localizes to extended processes in migrating neural crest cells. Given that Vg1 RBP is a member of the conserved VICKZ family of proteins, expressed in embryonic and neoplastic cells, these data shed light on the likely role of these RNA-binding proteins in regulating cell movements during both development and metastasis.

Key words: VICKZ protein family, RNA-binding proteins, Neural crest, Roof plate, Cell movement, Xenopus

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