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First published online November 17, 2003
doi: 10.1242/10.1242/dev.00893

Development 130, 6155-6163 (2003)
Published by The Company of Biologists 2003
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Mouse embryonic chimeras: tools for studying mammalian development

Patrick P. L. Tam1 and Janet Rossant2

1 Embryology Unit, Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia
2 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

e-mail: ptam{at}cmri.usyd.edu.au and rossant{at}mshri.on.ca

Embryonic chimeras of the mouse are well-established tools for studying cell lineage and cell potential. They are also a key part of the analysis of complex phenotypes of mutant mice. By combining embryonic stem cell technology, molecularly tagged mutations and sensitive cell lineage markers, chimeras can provide invaluable insights into the tissue-specific requirement and the mode of action of many mouse genes.




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