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First published online November 17, 2003
doi: 10.1242/10.1242/dev.00859
1 Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Strasse 10, 13125
Berlin, Germany
2 Department of Molecular Genetics, The University of Texas, M. D. Anderson
Cancer Center, Houston, TX 77030, USA
3 Center for Advanced Biotechnology and Medicine and Dept. of Pediatrics,
UMDNJ-Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854,
USA
4 Department of Immunology, University Hospital Utrecht, NL-3584 CX Utrecht, The
Netherlands
5 Department of Pharmacology, Kyoto University Graduate School of Medicine,
Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
* Author for correspondence (e-mail: wbirch{at}mdc-berlin.de)
Accepted 10 September 2003
Gene expression profiling of ß-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by ß-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of ß-catenin signals both in embryogenesis as well as in colon carcinoma cell lines and tissues. We have also defined groups of genes regulated by Wnt3/ß-catenin signalling during primitive streak and mesoderm formation. Our data assign a key role to ß-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation.
Key words: Microarray, Anteroposterior axis, Gastrulation, Signalling pathways, Tdgf1, Nanog
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