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First published online 19 November 2003
doi: 10.1242/dev.00894

Development 130, 6507-6518 (2003)
Published by The Company of Biologists 2003
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HLH-14 is a C. elegans Achaete-Scute protein that promotes neurogenesis through asymmetric cell division

C. Andrew Frank, Paul D. Baum* and Gian Garriga{dagger}

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3204, USA

{dagger} Author for correspondence (e-mail: garriga{at}uclink4.berkeley.edu)

Accepted 22 September 2003

Achaete-Scute basic helix-loop-helix (bHLH) proteins promote neurogenesis during metazoan development. In this study, we characterize a C. elegans Achaete-Scute homolog, HLH-14. We find that a number of neuroblasts express HLH-14 in the C. elegans embryo, including the PVQ/HSN/PHB neuroblast, a cell that generates the PVQ interneuron, the HSN motoneuron and the PHB sensory neuron. hlh-14 mutants lack all three of these neurons. The fact that HLH-14 promotes all three classes of neuron indicates that C. elegans proneural bHLH factors may act less specifically than their fly and mammalian homologs. Furthermore, neural loss in hlh-14 mutants results from a defect in an asymmetric cell division: the PVQ/HSN/PHB neuroblast inappropriately assumes characteristics of its sister cell, the hyp7/T blast cell. We argue that bHLH proteins, which control various aspects of metazoan development, can control cell fate choices in C. elegans by regulating asymmetric cell divisions. Finally, a reduction in the function of hlh-2, which encodes the C. elegans E/Daughterless bHLH homolog, results in similar neuron loss as hlh-14 mutants and enhances the effects of partially reducing hlh-14 function. We propose that HLH-14 and HLH-2 act together to specify neuroblast lineages and promote neuronal fate.

Key words: Caenorhabditis elegans, HLH-14, HLH-2, bHLH, Proneural, Neuroblast




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