spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 19 November 2003
doi: 10.1242/dev.00866

Development 130, 6635-6642 (2003)
Published by The Company of Biologists 2003
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.00866v1
130/26/6635    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dauger, S.
Right arrow Articles by Brunet, J.-F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dauger, S.
Right arrow Articles by Brunet, J.-F.

Research Article: Development and Disease

Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways

Stéphane Dauger1,*, Alexandre Pattyn2,*, Frédéric Lofaso1, Claude Gaultier1, Christo Goridis2, Jorge Gallego1 and Jean-François Brunet2,{dagger}

1 Laboratoire de Neurologie et Physiologie du Développement, INSERM EPI9935, Hôpital Robert Debré, 48 Bd Serurier, 75019 Paris, France
2 CNRS UMR 8542, Département de Biologie, Ecole Normale Supérieure, 46 rue d'Ulm, 75005 Paris, France

{dagger} Author for correspondence (e-mail: jfbrunet{at}biologie.ens.fr)

Accepted 15 September 2003

We report that the afferent relays of visceral (cardiovascular, digestive and respiratory) reflexes, differentiate under the control of the paired-like homeobox gene Phox2b: the neural crest-derived carotid body, a chemosensor organ, degenerates in homozygous mutants, as do the three epibranchial placode-derived visceral sensory ganglia (geniculate, petrosal and nodose), while their central target, the nucleus of the solitary tract, which integrates all visceral information, never forms. These data establish Phox2b as an unusual `circuit-specific' transcription factor devoted to the formation of autonomic reflex pathways. We also show that Phox2b heterozygous mutants have an altered response to hypoxia and hypercapnia at birth and a decreased tyrosine hydroxylase expression in the petrosal chemosensory neurons, thus providing mechanistic insight into congenital central hypoventilation syndrome, which is associated with heterozygous mutations in PHOX2B.

Key words: Transcription factor, Autonomic nervous system, Sensory neurons


Related articles in Development:

Keep breathing: the role of Phox2b

Development 2003 130: 2606. [Full Text]  



This article has been cited by other articles:


Home page
 J Child NeurolHome page
A. Khan, H. B. Sarnat, and R. Spaetgens
Congenital Muscle Fiber-Type Disproportion in a Patient With Congenital Central Hypoventilation Syndrome Due to PHOX2B Mutations
J Child Neurol, July 1, 2008; 23(7): 829 - 831.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
P. A. Gray
Transcription factors and the genetic organization of brain stem respiratory neurons
J Appl Physiol, May 1, 2008; 104(5): 1513 - 1521.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Gaultier and J Gallego
Neural control of breathing: insights from genetic mouse models
J Appl Physiol, May 1, 2008; 104(5): 1522 - 1530.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
V. Dubreuil, N. Ramanantsoa, D. Trochet, V. Vaubourg, J. Amiel, J. Gallego, J.-F. Brunet, and C. Goridis
A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons
PNAS, January 22, 2008; 105(3): 1067 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
J Amiel, E Sproat-Emison, M Garcia-Barcelo, F Lantieri, G Burzynski, S Borrego, A Pelet, S Arnold, X Miao, P Griseri, et al.
Hirschsprung disease, associated syndromes and genetics: a review
J. Med. Genet., January 1, 2008; 45(1): 1 - 14.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Ramanantsoa, V. Vaubourg, B. Matrot, G. Vardon, S. Dauger, and J. Gallego
Effects of temperature on ventilatory response to hypercapnia in newborn mice heterozygous for transcription factor Phox2b
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R2027 - R2035.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Barratt, A H Kendrick, F Buchanan, and A T Whittle
Central hypoventilation with PHOX2B expansion mutation presenting in adulthood
Thorax, October 1, 2007; 62(10): 919 - 920.
[Abstract] [Full Text] [PDF]

Home page
 NeoReviewsHome page
A. Vachharajani, S. Kuhlman, and B. Hackett
Index of Suspicion in the Nursery
NeoReviews, October 1, 2007; 8(10): e445 - e447.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. A. Sieber, R. Storm, M. Martinez-de-la-Torre, T. Muller, H. Wende, K. Reuter, E. Vasyutina, and C. Birchmeier
Lbx1 Acts as a Selector Gene in the Fate Determination of Somatosensory and Viscerosensory Relay Neurons in the Hindbrain
J. Neurosci., May 2, 2007; 27(18): 4902 - 4909.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Balbir, H. Lee, M. Okumura, S. Biswal, R. S. Fitzgerald, and M. Shirahata
A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice
Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L704 - L715.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L. S. Doherty, J. L. Kiely, P. C. Deegan, G. Nolan, S. McCabe, A. J. Green, S. Ennis, and W. T. McNicholas
Late-onset central hypoventilation syndrome: a family genetic study
Eur. Respir. J., February 1, 2007; 29(2): 312 - 316.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Nechiporuk, T. Linbo, K. D. Poss, and D. W. Raible
Specification of epibranchial placodes in zebrafish
Development, February 1, 2007; 134(3): 611 - 623.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. L. Stornetta, T. S. Moreira, A. C. Takakura, B. J. Kang, D. A. Chang, G. H. West, J. F. Brunet, D. K. Mulkey, D. A. Bayliss, and P. G. Guyenet
Expression of Phox2b by Brainstem Neurons Involved in Chemosensory Integration in the Adult Rat
J. Neurosci., October 4, 2006; 26(40): 10305 - 10314.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. D. Dufour, Z. Chettouh, C. Deyts, R. de Rosa, C. Goridis, J.-S. Joly, and J.-F. Brunet
Precraniate origin of cranial motoneurons
PNAS, June 6, 2006; 103(23): 8727 - 8732.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Ramanantsoa, V. Vaubourg, S. Dauger, B. Matrot, G. Vardon, Z. Chettouh, C. Gaultier, C. Goridis, and J. Gallego
Ventilatory response to hyperoxia in newborn mice heterozygous for the transcription factor Phox2b
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1691 - R1696.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
L de Pontual, A Pelet, D Trochet, F Jaubert, Y Espinosa-Parrilla, A Munnich, J-F Brunet, C Goridis, J Feingold, S Lyonnet, et al.
Mutations of the RET gene in isolated and syndromic Hirschsprung's disease in human disclose major and modifier alleles at a single locus
J. Med. Genet., May 1, 2006; 43(5): 419 - 423.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Durand, S. Dauger, A. Pattyn, C. Gaultier, C. Goridis, and J. Gallego
Sleep-disordered Breathing in Newborn Mice Heterozygous for the Transcription Factor Phox2b
Am. J. Respir. Crit. Care Med., July 15, 2005; 172(2): 238 - 243.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. M. Macey, M. A. Woo, K. E. Macey, T. G. Keens, M. M. Saeed, J. R. Alger, and R. M. Harper
Hypoxia reveals posterior thalamic, cerebellar, midbrain, and limbic deficits in congenital central hypoventilation syndrome
J Appl Physiol, March 1, 2005; 98(3): 958 - 969.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. M. Harper, P. M. Macey, M. A. Woo, K. E. Macey, T. G. Keens, D. Gozal, and J. R. Alger
Hypercapnic Exposure in Congenital Central Hypoventilation Syndrome Reveals CNS Respiratory Control Mechanisms
J Neurophysiol, March 1, 2005; 93(3): 1647 - 1658.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Matrot, E. Durand, S. Dauger, G. Vardon, C. Gaultier, and J. Gallego
Automatic classification of activity and apneas using whole body plethysmography in newborn mice
J Appl Physiol, January 1, 2005; 98(1): 365 - 370.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. E. Macey, P. M. Macey, M. A. Woo, R. K. Harper, J. R. Alger, T. G. Keens, and R. M. Harper
fMRI signal changes in response to forced expiratory loading in congenital central hypoventilation syndrome
J Appl Physiol, November 1, 2004; 97(5): 1897 - 1907.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. Amiel, D. Trochet, M. Clement-Ziza, A. Munnich, and S. Lyonnet
Polyalanine expansions in human
Hum. Mol. Genet., October 1, 2004; 13(suppl_2): R235 - R243.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. H. Cross, J. E. Morgan, A. Pattyn, K. West, L. McKie, A. Hart, C. Thaung, J.-F. Brunet, and I. J. Jackson
Haploinsufficiency for Phox2b in mice causes dilated pupils and atrophy of the ciliary ganglion: mechanistic insights into human congenital central hypoventilation syndrome
Hum. Mol. Genet., July 15, 2004; 13(14): 1433 - 1439.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. E. Weese-Mayer and E. M. Berry-Kravis
Genetics of Congenital Central Hypoventilation Syndrome: Lessons from a Seemingly Orphan Disease
Am. J. Respir. Crit. Care Med., July 1, 2004; 170(1): 16 - 21.
[Full Text] [PDF]


© The Company of Biologists Ltd 2003