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doi: 10.1242/10.1242/dev.00308

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Development 130, 929-940 (2003)
Copyright © 2003 The Company of Biologists Limited

Zebrafish foxi1 mediates otic placode formation and jaw development

Keely S. Solomon1,*, Tetsuhiro Kudoh2,*,{dagger}, Igor B. Dawid2 and Andreas Fritz1,§

1 Department of Biology, Emory University, Atlanta, GA 30322, USA
2 Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
{dagger} Present address: Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK

§ Author for correspondence (e-mail: afrtiz{at}biology.emory.edu)

Accepted 18 November 2002

The otic placode is a transient embryonic structure that gives rise to the inner ear. Although inductive signals for otic placode formation have been characterized, less is known about the molecules that respond to these signals within otic primordia. Here, we identify a mutation in zebrafish, hearsay, which disrupts the initiation of placode formation. We show that hearsay disrupts foxi1, a forkhead domain-containing gene, which is expressed in otic precursor cells before placodes become visible; foxi1 appears to be the earliest marker known for the otic anlage. We provide evidence that foxi1 regulates expression of pax8, indicating a very early role for this gene in placode formation. In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos.

Key words: Foxi1, Forkhead, Zebrafish, Otic Placode, Ear, Jaw


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