|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
doi: 10.1242/10.1242/dev.00270
1 Carnegie Institution of Washington, Department of Embryology, 115 W.
University Parkway, Baltimore, MD, 21210, USA
2 IGBMC, CNRS/INSERM/ULP, 1 rue Laurent Fries, BP10142, CU de Strasbourg, 67404
Illkirch cedex, France
* Author for correspondence (e-mail: halpern{at}ciwemb.edu)
Accepted 26 November 2002
The dorsal diencephalon (or epithalamus) of larval zebrafish displays distinct left-right asymmetries. The pineal complex consists of the pineal organ anlage and an unpaired, left-sided accessory organ – the parapineal. The neighboring brain nuclei, the left and right dorsal habenulae, show consistent differences in their size, density of neuropil and gene expression. Mutational analyses demonstrate a correlation between the left-right position of the parapineal and the laterality of the habenular nuclei. We show that selective ablation of the parapineal organ results in the loss of habenular asymmetry. The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion.
Key words: Habenula, Epithalamus, Epiphysis, Pineal organ, Brain laterality
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  L. A. Quina, S. Wang, L. Ng, and E. E. Turner Brn3a and Nurr1 Mediate a Gene Regulatory Pathway for Habenula Development J. Neurosci., November 11, 2009; 29(45): 14309 - 14322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. C. Serluca, B. Xu, N. Okabe, K. Baker, S.-Y. Lin, J. Sullivan-Brown, D. J. Konieczkowski, K. M. Jaffe, J. M. Bradner, M. C. Fishman, et al. Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning Development, May 15, 2009; 136(10): 1621 - 1631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Roussigne, I. H. Bianco, S. W. Wilson, and P. Blader Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei Development, May 1, 2009; 136(9): 1549 - 1557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. H Bianco and S. W Wilson The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain Phil Trans R Soc B, April 12, 2009; 364(1519): 1005 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Facchin, H. A Burgess, M. Siddiqi, M. Granato, and M. E Halpern Determining the function of zebrafish epithalamic asymmetry Phil Trans R Soc B, April 12, 2009; 364(1519): 1021 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Collery, S. McLoughlin, V. Vendrell, J. Finnegan, J. W. Crabb, J. C. Saari, and B. N. Kennedy Duplication and Divergence of Zebrafish CRALBP Genes Uncovers Novel Role for RPE- and Muller-CRALBP in Cone Vision Invest. Ophthalmol. Vis. Sci., September 1, 2008; 49(9): 3812 - 3820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Snelson, K. Santhakumar, M. E. Halpern, and J. T. Gamse Tbx2b is required for the development of the parapineal organ Development, May 1, 2008; 135(9): 1693 - 1702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Y. Miyasaka, Y. S. Kida, T. Sato, M. Minami, and T. Ogura Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin PNAS, July 3, 2007; 104(27): 11274 - 11279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. S. Kida, T. Sato, K. Y. Miyasaka, A. Suto, and T. Ogura Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord PNAS, April 17, 2007; 104(16): 6708 - 6713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schottenfeld, J. Sullivan-Brown, and R. D. Burdine Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw Development, April 15, 2007; 134(8): 1605 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-S. Kuan, H.-H. Yu, C. B. Moens, and M. E. Halpern Neuropilin asymmetry mediates a left-right difference in habenular connectivity Development, March 1, 2007; 134(5): 857 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Webb and T. F. Schilling Zebrafish in comparative context: A symposium Integr. Comp. Biol., October 1, 2006; 46(5): 569 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Pineda, K. R. Svoboda, M. A. Wright, A. D. Taylor, A. E. Novak, J. T. Gamse, J. S. Eisen, and A. B. Ribera Knockdown of Nav 1.6a Na+ channels affects zebrafish motoneuron development Development, October 1, 2006; 133(19): 3827 - 3836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Halpern, O. Gunturkun, W. D. Hopkins, and L. J. Rogers Lateralization of the Vertebrate Brain: Taking the Side of Model Systems J. Neurosci., November 9, 2005; 25(45): 10351 - 10357. [Full Text] [PDF]
|
|
|
|
|
|
J. T. Gamse, Y.-S. Kuan, M. Macurak, C. Brosamle, B. Thisse, C. Thisse, and M. E. Halpern Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target Development, November 1, 2005; 132(21): 4869 - 4881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Essner, J. D. Amack, M. K. Nyholm, E. B. Harris, and H. J. Yost Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut Development, March 15, 2005; 132(6): 1247 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hashimoto, M. Rebagliati, N. Ahmad, O. Muraoka, T. Kurokawa, M. Hibi, and T. Suzuki The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish Development, April 15, 2004; 131(8): 1741 - 1753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Long, N. Ahmad, and M. Rebagliati The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry Development, June 1, 2003; 130(11): 2303 - 2316. [Abstract] [Full Text] [PDF]
|
|
