|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
doi: 10.1242/10.1242/dev.00417
1 Department of Psychiatry, Nina Ireland Laboratory of Developmental
Neurobiology, Langley Porter Psychiatric Institute, 401 Parnassus Avenue,
University of California San Francisco, CA 94143, USA
2 Department of Biological Sciences, Howard Hughes Medical Institute, 371 Serra
Mall, Stanford University, Stanford, CA 94305, USA
* Present address: Instituto de Neurociencias, CSIC-Universidad Miguel
Hernández, 03550 San Juan, Alicante, Spain
Present address: Merck & Co., 126 East Lincoln Avenue, Rahway, NJ 07065,
USA
Present address: Instituto de Neurobiología Ramón y Cajal, Avda.
Doctor Arce, 37, 28002 Madrid, Spain
Author for correspondence (e-mail:
jlrr{at}cgl.ucsf.edu)
Accepted 30 January 2003
Tangential migration from the basal telencephalon to the cortex is a highly directional process, yet the mechanisms involved are poorly understood. Here we show that the basal telencephalon contains a repulsive activity for tangentially migrating cells, whereas the cerebral cortex contains an attractive activity. In vitro experiments demonstrate that the repulsive activity found in the basal telencephalon is maintained in mice deficient in both Slit1 and Slit2, suggesting that factors other than these are responsible for this activity. Correspondingly, in vivo analysis demonstrates that interneurons migrate to the cortex in the absence of Slit1 and Slit2, or even in mice simultaneously lacking Slit1, Slit2 and netrin 1. Nevertheless, loss of Slit2 and, even more so, Slit1 and Slit2 results in defects in the position of other specific neuronal populations within the basal telencephalon, such as the cholinergic neurons of the basal magnocellular complex. These results demonstrate that whereas Slit1 and Slit2 are not necessary for tangential migration of interneurons to the cortex, these proteins regulate neuronal migration within the basal telencephalon by controlling cell positioning close to the midline.
Key words: Cell migration, Interneuron, Cholinergic neurons, Basal magnocellular complex, Telencephalon, Cortex, Basal telencephalon, medial ganglionic eminence, Mouse, Slit1, Slit2, netrin 1
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Barber, T. Di Meglio, W. D. Andrews, L. R. Hernandez-Miranda, F. Murakami, A. Chedotal, and J. G. Parnavelas The Role of Robo3 in the Development of Cortical Interneurons Cereb Cortex, July 1, 2009; 19(suppl_1): i22 - i31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Martini, M. Valiente, G. Lopez Bendito, G. Szabo, F. Moya, M. Valdeolmillos, and O. Marin Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration Development, January 1, 2009; 136(1): 41 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Lopez-Bendito, J. A. Sanchez-Alcaniz, R. Pla, V. Borrell, E. Pico, M. Valdeolmillos, and O. Marin Chemokine Signaling Controls Intracortical Migration and Final Distribution of GABAergic Interneurons J. Neurosci., February 13, 2008; 28(7): 1613 - 1624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Li, H. Adesnik, J. Li, J. Long, R. A. Nicoll, J. L. R. Rubenstein, and S. J. Pleasure Regional Distribution of Cortical Interneurons and Development of Inhibitory Tone Are Regulated by Cxcl12/Cxcr4 Signaling J. Neurosci., January 30, 2008; 28(5): 1085 - 1098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mingorance-Le Meur, B. Zheng, E. Soriano, and J. A. del Rio Involvement of the Myelin-Associated Inhibitor Nogo-A in Early Cortical Development and Neuronal Maturation Cereb Cortex, October 1, 2007; 17(10): 2375 - 2386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. N. Le, G. Du, M. Fonseca, Q.-P. Zhou, J. T. Wigle, and D. D. Eisenstat Dlx Homeobox Genes Promote Cortical Interneuron Migration from the Basal Forebrain by Direct Repression of the Semaphorin Receptor Neuropilin-2 J. Biol. Chem., June 29, 2007; 282(26): 19071 - 19081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. E. Carney, T. B. Alfonso, D. Cohen, H. Dai, S. Nery, B. Stoica, J. Slotkin, B. S. Bregman, G. Fishell, and J. G. Corbin Cell Migration along the Lateral Cortical Stream to the Developing Basal Telencephalic Limbic System. J. Neurosci., November 8, 2006; 26(45): 11562 - 11574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. C. Cuzon, P. W. Yeh, Q. Cheng, and H. H. Yeh Ambient GABA Promotes Cortical Entry of Tangentially Migrating Cells Derived from the Medial Ganglionic Eminence Cereb Cortex, October 1, 2006; 16(10): 1377 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Andrews, A. Liapi, C. Plachez, L. Camurri, J. Zhang, S. Mori, F. Murakami, J. G. Parnavelas, V. Sundaresan, and L. J. Richards Robo1 regulates the development of major axon tracts and interneuron migration in the forebrain Development, June 1, 2006; 133(11): 2243 - 2252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Xu, C. P. Wonders, and S. A. Anderson Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon Development, November 15, 2005; 132(22): 4987 - 4998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Schmid, R. Jo, S. Shelton, J. A. Kreidberg, and E. S. Anton Reelin, Integrin and Dab1 Interactions during Embryonic Cerebral Cortical Development Cereb Cortex, October 1, 2005; 15(10): 1632 - 1636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bellion, J.-P. Baudoin, C. Alvarez, M. Bornens, and C. Metin Nucleokinesis in Tangentially Migrating Neurons Comprises Two Alternating Phases: Forward Migration of the Golgi/Centrosome Associated with Centrosome Splitting and Myosin Contraction at the Rear J. Neurosci., June 15, 2005; 25(24): 5691 - 5699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tripodi, A. Filosa, M. Armentano, and M. Studer The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrain Development, December 15, 2004; 131(24): 6119 - 6129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Schmid, S. Shelton, A. Stanco, Y. Yokota, J. A. Kreidberg, and E. S. Anton {alpha}3{beta}1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development Development, December 15, 2004; 131(24): 6023 - 6031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C G F de Kovel, F A Hol, J G A M Heister, J J H T Willemen, L A Sandkuijl, B Franke, and G W Padberg Genomewide scan identifies susceptibility locus for dyslexia on Xq27 in an extended Dutch family J. Med. Genet., September 1, 2004; 41(9): 652 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Nguyen-Ba-Charvet, N. Picard-Riera, M. Tessier-Lavigne, A. Baron-Van Evercooren, C. Sotelo, and A. Chedotal Multiple Roles for Slits in the Control of Cell Migration in the Rostral Migratory Stream J. Neurosci., February 11, 2004; 24(6): 1497 - 1506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Aarum, K. Sandberg, S. L. B. Haeberlein, and M. A. A. Persson Migration and differentiation of neural precursor cells can be directed by microglia PNAS, December 23, 2003; 100(26): 15983 - 15988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang, L. Vutskits, M. S. Pepper, and J. Z. Kiss VEGF is a chemoattractant for FGF-2-stimulated neural progenitors J. Cell Biol., December 22, 2003; 163(6): 1375 - 1384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tanaka, Y. Nakaya, Y. Yanagawa, K. Obata, and F. Murakami Multimodal tangential migration of neocortical GABAergic neurons independent of GPI-anchored proteins Development, December 1, 2003; 130(23): 5803 - 5813. [Abstract] [Full Text] [PDF]
|
|
