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First published online 3 December 2003
doi: 10.1242/dev.00916

Development 131, 93-104 (2004)
Published by The Company of Biologists 2004
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Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation

Dave Hansen, Laura Wilson-Berry, Thanh Dang and Tim Schedl*

Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA

* Author for correspondence (e-mail: ts{at}genetics.wustl.edu)

Accepted 13 October 2003

Maintenance of the stem cell population in the C. elegans germline requires GLP-1/Notch signaling. We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved in regulating GLD-1 activity, we identified mutations in the nos-3 gene, the protein product of which is similar to the Drosophila translational regulator Nanos. Our data demonstrate that nos-3 promotes GLD-1 accumulation redundantly with gld-2, and that nos-3 functions genetically downstream or parallel to fbf, an inhibitor of GLD-1 translation. We show that the GLD-1 accumulation pattern is important in controlling the proliferation versus meiotic development decision, with low GLD-1 levels allowing proliferation and increased levels promoting meiotic entry.

Key words: Germline development, Stem cells, Proliferation, Tumor, Meiotic entry, Notch signaling, gld-1, nos-3, glp-1


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