spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 16 June 2004
doi: 10.1242/dev.01196

Development 131, 3263-3272 (2004)
Published by The Company of Biologists 2004
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01196v1
131/14/3263    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mootz, D.
Right arrow Articles by Hunter, C. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mootz, D.
Right arrow Articles by Hunter, C. P.

The STAR/Maxi-KH domain protein GLD-1 mediates a developmental switch in the translational control of C. elegans PAL-1

Darcy Mootz, Diana M. Ho* and Craig P. Hunter{dagger}

Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA

{dagger} Author for correspondence (e-mail: hunter{at}mcb.harvard.edu)

Accepted 30 March 2004

Translational control is an essential mechanism of gene control utilized throughout development, yet the molecular mechanisms underlying translational activation and repression are poorly understood. We have investigated the translational control of the C. elegans caudal homolog, pal-1, and found that GLD-1, a member of the evolutionarily conserved STAR/Maxi-KH domain family, acts through a minimal pal-1 3' UTR element to repress pal-1 translation in the distal germline. We also provide data suggesting that GLD-1 may repress pal-1 translation after initiation. Finally, we show that GLD-1 represses the distal germline expression of the KH domain protein MEX-3, which was previously shown to repress PAL-1 expression in the proximal germline and which appears specialized to control PAL-1 expression patterns in the embryo. Hence, GLD-1 mediates a developmental switch in the control of PAL-1 repression, allowing MEX-3 to accumulate and take over the task of PAL-1 repression in the proximal germline, where GLD-1 protein levels decline.

Key words: GLD-1, PAL-1, Translational control, C. elegans, STAR/Maxi-KH Domain, Post-initiation repression




This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
K. Buchet-Poyau, J. Courchet, H. L. Hir, B. Seraphin, J.-Y. Scoazec, L. Duret, C. Domon-Dell, J.-N. Freund, and M. Billaud
Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies
Nucleic Acids Res., February 28, 2007; 35(4): 1289 - 1300.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. Ciosk, M. DePalma, and J. R. Priess
Translational Regulators Maintain Totipotency in the Caenorhabditis elegans Germline
Science, February 10, 2006; 311(5762): 851 - 853.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
V. E. Vought, M. Ohmachi, M.-H. Lee, and E. M. Maine
EGO-1, a Putative RNA-Directed RNA Polymerase, Promotes Germline Proliferation in Parallel With GLP-1/Notch Signaling and Regulates the Spatial Organization of Nuclear Pore Complexes and Germline P Granules in Caenorhabditis elegans
Genetics, July 1, 2005; 170(3): 1121 - 1132.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004