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First published online July 19, 2004
doi: 10.1242/10.1242/dev.01227

Development 131, 3581-3592 (2004)
Published by The Company of Biologists 2004
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Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains

Tetsuhiro Kudoh1,2,*, Miguel L. Concha1,{dagger}, Corinne Houart1,3, Igor B. Dawid2 and Stephen W. Wilson1,*

1 Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
2 Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA
3 MRC Centre for Developmental Neurobiology, New Hunt's House, Kings College London, London SE1 9RT, UK

* Authors for correspondence (e-mail: t.kudoh{at}ucl.ac.uk or s.wilson{at}ucl.ac.uk)

Accepted 14 April 2004

Studies in fish and amphibia have shown that graded Bmp signalling activity regulates dorsal-to-ventral (DV) patterning of the gastrula embryo. In the ectoderm, it is thought that high levels of Bmp activity promote epidermal development ventrally, whereas secreted Bmp antagonists emanating from the organiser induce neural tissue dorsally. However, in zebrafish embryos, the domain of cells destined to contribute to the spinal cord extends all the way to the ventral side of the gastrula, a long way from the organiser. We show that in vegetal (trunk and tail) regions of the zebrafish gastrula, neural specification is initiated at all DV positions of the ectoderm in a manner that is unaffected by levels of Bmp activity and independent of organiser-derived signals. Instead, we find that Fgf activity is required to induce vegetal prospective neural markers and can do so without suppressing Bmp activity. We further show that Bmp signalling does occur within the vegetal prospective neural domain and that Bmp activity promotes the adoption of caudal fate by this tissue.

Key words: Zebrafish, Default model, Neural induction


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