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First published online 30 June 2004
doi: 10.1242/dev.01239
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1 Department of Cell Biology, Duke University, Durham, NC 27710, USA
2 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle,
WA 98109, USA
3 Department of Molecular Biology and Pharmacology, Washington University
Medical School, St Louis, MO 63110, USA
* Author for correspondence (e-mail: b.capel{at}cellbio.duke.edu)
Accepted 14 April 2004
Recently, we demonstrated that loss of Fgf9 results in a block of testis development and a male to female sex-reversed phenotype; however, the function of Fgf9 in sex determination was unknown. We now show that Fgf9 is necessary for two steps of testis development just downstream of the male sex-determining gene, Sry: (1) for the proliferation of a population of cells that give rise to Sertoli progenitors; and (2) for the nuclear localization of an FGF receptor (FGFR2) in Sertoli cell precursors. The nuclear localization of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate.
Key words: FGF, Sex determination, Sertoli cell, Sry, Gonad, Testes
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