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First published online July 19, 2004
doi: 10.1242/10.1242/dev.01249

Development 131, 3761-3772 (2004)
Published by The Company of Biologists 2004
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Founder myoblasts and fibre number during adult myogenesis in Drosophila

Devkanya Dutta1, Sumita Anant1,2, Mar Ruiz-Gomez3, Michael Bate1,4,* and K. VijayRaghavan1,*

1 National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560065, India
2 The Salk Institute Peptide Biology Lab, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
3 Centro de Biologia Molecular "Severo Ochoa", UAM-CSIC, Madrid 28049, Spain
4 Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK

* Authors for correspondence (e-mail: cmbate{at}ncbs.res.in and vijay{at}ncbs.res.in)

Accepted 20 April 2004

We have examined the mechanisms underlying the setting of myotubes and choice of myotube number in adult Drosophila. We find that the pattern of adult myotubes is prefigured by a pattern of duf-lacZ-expressing myoblasts at appropriate locations. Selective expression of duf-lacZ in single myoblasts emerges from generalized, low-level expression in all adult myoblasts during the third larval instar. The number of founders, thus chosen, corresponds to the number of fibres in a muscle. In contrast to the embryo, the selection of individual adult founder cells during myogenesis does not depend on Notch-mediated lateral inhibition. Our results suggest a general mechanism by which multi-fibre muscles can be patterned.

Key words: Myogenesis, Myotube, Muscle, Founder cell


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© The Company of Biologists Ltd 2004