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First published online 14 July 2004
doi: 10.1242/dev.01258

Development 131, 3839-3847 (2004)
Published by The Company of Biologists 2004
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Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye

Ju-Lan Chao1,2, Yu-Chen Tsai1,2, Sue-Jean Chiu2 and Y. Henry Sun1,2,*

1 Institute of Genetics, National Yang-Ming University, Taipei 111, Taiwan, Republic of China
2 Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, Republic of China

* Author for correspondence (e-mail: mbyhsun{at}ccvax.sinica.edu.tw)

Accepted 29 April 2004

Notch (N) signal is activated at the dorsoventral (DV) border of the Drosophila eye disc and is important for growth of the eye disc. In this study, we showed that the Pax protein Eyg is a major effector mediating the growth promotion function of N. eyg transcription is induced by N signaling occurring at the DV border. Like N, eyg controls growth of the eye disc. Loss of N signaling can be compensated by overexpressing eyg, whereas loss of the downstream eyg blocked the function of N signaling. In addition, we showed that N and eyg could induce expression of upd, which encodes the ligand for the Jak/STAT pathway and acts over long distance to promote cell proliferation. Loss of eyg or N can be compensated by overexpressing upd. These results suggest that upd is a major effector mediating the function of eyg and N. The functional link from N to eyg to upd explains how the localized Notch activation can achieve global growth control.

Key words: Drosophila, Eye, Cell proliferation, Growth, Notch, upd, eyg




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