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First published online August 18, 2004
doi: 10.1242/10.1242/dev.01339
Review |
1 Department of Cell and Developmental Biology, Program in Neuroscience, Cell
and Molecular Biology Program, University of Michigan Medical School, Ann
Arbor, MI 48109-0616, USA
2 Section on Developmental Neuroscience, National Institute on Deafness and
other Communication Disorders, National Institutes of Health, Rockville, MD
20850, USA
* Author for correspondence (e-mail: kelleymt{at}nidcd.nih.gov)
Accepted 7 July 2004
SUMMARY
The highly orchestrated processes that generate the vertebrate inner ear from the otic placode provide an excellent and circumscribed testing ground for fundamental cellular and molecular mechanisms of development. The recent pace of discovery in developmental auditory biology has been unusually rapid, with hundreds of papers published in the past 4 years. This review summarizes studies addressing several key issues that shape our current thinking about inner ear development, with particular emphasis on early patterning events, sensory hair cell specification and planar cell polarity.
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Y. Asai, D. K. Chan, C. J. Starr, J. A. Kappler, R. Kollmar, and A. J. Hudspeth Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear PNAS, June 13, 2006; 103(24): 9069 - 9074. [Abstract] [Full Text] [PDF]
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K. Martin and A. K. Groves Competence of cranial ectoderm to respond to Fgf signaling suggests a two-step model of otic placode induction Development, March 1, 2006; 133(5): 877 - 887. [Abstract] [Full Text] [PDF]
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T. Ohyama, O. A. Mohamed, M. M. Taketo, D. Dufort, and A. K. Groves Wnt signals mediate a fate decision between otic placode and epidermis Development, March 1, 2006; 133(5): 865 - 875. [Abstract] [Full Text] [PDF]
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A. E. Kiernan, R. Cordes, R. Kopan, A. Gossler, and T. Gridley The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear Development, October 1, 2005; 132(19): 4353 - 4362. [Abstract] [Full Text] [PDF]
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N. Daudet and J. Lewis Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation Development, February 1, 2005; 132(3): 541 - 551. [Abstract] [Full Text] [PDF]
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