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First published online 4 August 2004
doi: 10.1242/dev.01308

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Retinoic acid signalling specifies intermediate character in the developing telencephalon

¹ Umeå Center for Molecular Medicine, Building 6M, 4th floor, Umeå University, S-901 87 Umeå, Sweden
² Department of Biochemical Pharmacology, Bristol-Myers Squibb Pharmaceutical Research Institute, Buffalo, NY 14213, USA
³ Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

^* Author for correspondence (e-mail: thomas.edlund{at}molbiol.umu.se)

Accepted 9 June 2004

The organisation of the telencephalon into its major structures depends on its early regionalisation along the dorsoventral axis. Previous studies have provided evidence that sonic hedgehog (SHH) is required for the generation of telencephalic cells of ventral character, and that sequential WNT and fibroblast growth factor (FGF) signalling specifies cells of dorsal telencephalic character. However, the signalling mechanisms that specify telencephalic cells of an intermediate character remain to be defined. We provide evidence here that retinoic acid has a crucial role in specifying telencephalic progenitor cells of intermediate character.

Key words: Chick, Mouse, Retinoic acid

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