|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online 4 August 2004
doi: 10.1242/dev.01304
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Cell Biology and Anatomy, University of Arizona Health Sciences
Center, 1501 North Campbell Avenue, Tucson, AZ 85724-5044, USA
2 Department of Surgery, University of Arizona Health Sciences Center, 1501
North Campbell Avenue, Tucson, AZ 85724-5044, USA
3 Department of Molecular and Cellular Biology, Harvard University, 16 Divinity
Avenue, Cambridge, MA 02138, USA
Author for correspondence (e-mail:
pkrieg{at}email.arizona.edu)
Accepted 9 June 2004
During embryonic development, the first blood vessels are formed through the aggregation and subsequent assembly of angioblasts (endothelial precursors) into a network of endothelial tubes, a process known as vasculogenesis. These first vessels generally form in mesoderm that is adjacent to endodermal tissue. Although specification of the angioblast lineage is independent of endoderm interactions, a signal from the endoderm is necessary for angioblasts to assemble into a vascular network and to undergo vascular tube formation. In this study, we show that endodermally derived sonic hedgehog is both necessary and sufficient for vascular tube formation in avian embryos. We also show that Hedgehog signaling is required for vascular tube formation in mouse embryos, and for vascular cord formation in cultured mouse endothelial cells. These results demonstrate a previously uncharacterized role for Hedgehog signaling in vascular development, and identify Hedgehog signaling as an important component of the molecular pathway leading to vascular tube formation.
Key words: Vasculogenesis, Tubulogenesis, Endoderm, VEGF, Mouse, Chick
Related articles in Development:
This article has been cited by other articles:
|
|
 |
|
  S. P. Mudumana, D. Hentschel, Y. Liu, A. Vasilyev, and I. A. Drummond odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate Development, October 15, 2008; 135(20): 3355 - 3367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Lavine, F. Long, K. Choi, C. Smith, and D. M. Ornitz Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development Development, September 15, 2008; 135(18): 3161 - 3171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Hong, T. Kume, and R. T. Peterson Role of Crosstalk Between Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathways in Artery-Vein Specification Circ. Res., September 12, 2008; 103(6): 573 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Passman, X. R. Dong, S.-P. Wu, C. T. Maguire, K. A. Hogan, V. L. Bautch, and M. W. Majesky A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells PNAS, July 8, 2008; 105(27): 9349 - 9354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Zoeller, A. McQuillan, J. Whitelock, S.-Y. Ho, and R. V. Iozzo A central function for perlecan in skeletal muscle and cardiovascular development J. Cell Biol., April 21, 2008; 181(2): 381 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. A. Yoo, M. H. Kang, J. S. Kim, and S. C. Oh Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-{beta}-mediated activation of the ALK5-Smad 3 pathway Carcinogenesis, March 1, 2008; 29(3): 480 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Astorga and P. Carlsson Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4 Development, October 15, 2007; 134(20): 3753 - 3761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. White, K. J. Lavine, and D. M. Ornitz FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network Development, October 15, 2007; 134(20): 3743 - 3752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Agouni, H. A. Mostefai, C. Porro, N. Carusio, J. Favre, V. Richard, D. Henrion, M. C. Martinez, and R. Andriantsitohaina Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release FASEB J, September 1, 2007; 21(11): 2735 - 2741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Levenberg, J. Zoldan, Y. Basevitch, and R. Langer Endothelial potential of human embryonic stem cells Blood, August 1, 2007; 110(3): 806 - 814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schmidt, K. Brixius, and W. Bloch Endothelial Precursor Cell Migration During Vasculogenesis Circ. Res., July 20, 2007; 101(2): 125 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Hochman, A. Castiel, J. Jacob-Hirsch, N. Amariglio, and S. Izraeli Molecular Pathways Regulating Pro-migratory Effects of Hedgehog Signaling J. Biol. Chem., November 10, 2006; 281(45): 33860 - 33870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Martinez, F. Larbret, F. Zobairi, J. Coulombe, N. Debili, W. Vainchenker, M. Ruat, and J.-M. Freyssinet Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens Blood, November 1, 2006; 108(9): 3012 - 3020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Lavine, A. C. White, C. Park, C. S. Smith, K. Choi, F. Long, C.-c. Hui, and D. M. Ornitz Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes & Dev., June 15, 2006; 20(12): 1651 - 1666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Asai, H. Takenaka, K. F. Kusano, M. Ii, C. Luedemann, C. Curry, E. Eaton, A. Iwakura, Y. Tsutsumi, H. Hamada, et al. Topical Sonic Hedgehog Gene Therapy Accelerates Wound Healing in Diabetes by Enhancing Endothelial Progenitor Cell-Mediated Microvascular Remodeling Circulation, May 23, 2006; 113(20): 2413 - 2424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, F. Cerrato, H. Xu, F. Vitelli, M. Morishima, J. Vincentz, Y. Furuta, L. Ma, J. F. Martin, A. Baldini, et al. Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development Development, December 1, 2005; 132(23): 5307 - 5315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Jin, D. Beis, T. Mitchell, J.-N. Chen, and D. Y. R. Stainier Cellular and molecular analyses of vascular tube and lumen formation in zebrafish Development, December 1, 2005; 132(23): 5199 - 5209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. X. Liang, R. Summer, X. Sun, and A. Fine Gene expression profiling and localization of Hoechst-effluxing CD45- and CD45+ cells in the embryonic mouse lung Physiol Genomics, October 17, 2005; 23(2): 172 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Colnot, L. de la Fuente, S. Huang, D. Hu, C. Lu, B. St-Jacques, and J. A. Helms Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development Development, March 1, 2005; 132(5): 1057 - 1067. [Abstract] [Full Text] [PDF]
|
|
