spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online September 1, 2004
doi: 10.1242/10.1242/dev.01309

Development 131, 4501-4509 (2004)
Published by The Company of Biologists 2004
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schröter, R. H.
Right arrow Articles by Renkawitz-Pohl, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schröter, R. H.
Right arrow Articles by Renkawitz-Pohl, R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

kette and blown fuse interact genetically during the second fusion step of myogenesis in Drosophila

Roxane H. Schröter1,*, Simone Lier1,*,{dagger}, Anne Holz1,{ddagger}, Sven Bogdan3, Christian Klämbt3, Lothar Beck2 and Renate Renkawitz-Pohl1,§

1 Philipps-Universität Marburg, Fachbereich Biologie, Entwicklungsbiologie, Karl-von-Frisch Strasse 8, 35043 Marburg, Germany
2 Philipps-Universität Marburg, Fachbereich Biologie, Spezielle Zoologie, Karl-von-Frisch Strasse 8, 35043 Marburg, Germany
3 Institut für Neuround Verhaltensbiologie, Westfälische Wilhelms-Universität Münster, Badestrasse 9, 48149 Münster, Germany

§ Author for correspondence (e-mail: renkawit{at}staff.uni-marburg.de)

Accepted 9 June 2004

Drosophila myoblast fusion proceeds in two steps. The first one gives rise to small syncytia, the muscle precursor cells, which then recruit further fusion competent myoblasts to reach the final muscle size. We have identified Kette as an essential component for myoblast fusion. In kette mutants, founder cells and fusion-competent myoblasts are determined correctly and overcome the very first fusion. But then, at the precursor cell stage, fusion is interrupted. At the ultrastructural level, fusion is characterised by cell-cell recognition, alignment, formation of prefusion complexes, electron dense plaques and membrane breakdown. In kette mutants, electron dense plaques of aberrant length accumulate and fusion is interrupted owing to a complete failure of membrane breakdown. Furthermore, we show that kette interacts genetically with blown fuse (blow) which is known to be required to proceed from prefusion complexes to the formation of the electron dense plaques. Interestingly, a surplus of Kette can replace Blow function during myogenesis. We propose a model in which Dumbfounded/Sticks and stones-dependent cell adhesion is mediated over Rolling Pebbles, Myoblast city, Crk, Blown fuse and Kette, and thus induces membrane fusion.

Key words: Myoblast fusion, Attachment, Prefusion complex, Electron dense plaque kette, blow, rols, sns, mbc, crk


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
C. D. O'Donnell and D. Shukla
A Novel Function of Heparan Sulfate in the Regulation of Cell-Cell Fusion
J. Biol. Chem., October 23, 2009; 284(43): 29654 - 29665.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. J. Nowak, P. C. Nahirney, A.-K. Hadjantonakis, and M. K. Baylies
Nap1-mediated actin remodeling is essential for mammalian myoblast fusion
J. Cell Sci., September 15, 2009; 122(18): 3282 - 3293.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Vasyutina, B. Martarelli, C. Brakebusch, H. Wende, and C. Birchmeier
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse
PNAS, June 2, 2009; 106(22): 8935 - 8940.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Shelton, K. S. Kocherlakota, S. Zhuang, and S. M. Abmayr
The immunoglobulin superfamily member Hbs functions redundantly with Sns in interactions between founder and fusion-competent myoblasts
Development, April 1, 2009; 136(7): 1159 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Berger, G. Schafer, D. A. Kesper, A. Holz, T. Eriksson, R. H. Palmer, L. Beck, C. Klambt, R. Renkawitz-Pohl, and S.-F. Onel
WASP and SCAR have distinct roles in activating the Arp2/3 complex during myoblast fusion
J. Cell Sci., April 15, 2008; 121(8): 1303 - 1313.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. E. Richardson, K. Beckett, S. J. Nowak, and M. K. Baylies
SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion
Development, December 15, 2007; 134(24): 4357 - 4367.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. R. Doherty, A. Cave, D. B. Davis, A. J. Delmonte, A. Posey, J. U. Earley, M. Hadhazy, and E. M. McNally
Normal myoblast fusion requires myoferlin
Development, December 15, 2005; 132(24): 5565 - 5575.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. D. Menon, Z. Osman, K. Chenchill, and W. Chia
A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila
J. Cell Biol., June 20, 2005; 169(6): 909 - 920.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
E. H. Chen and E. N. Olson
Unveiling the Mechanisms of Cell-Cell Fusion
Science, April 15, 2005; 308(5720): 369 - 373.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004