|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online 17 December 2003
doi: 10.1242/dev.00930
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
,
The Skirball Institute and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
Author for correspondence (e-mail:
ria{at}saturn.med.nyu.edu)
Accepted 17 October 2003
Stem cells are crucial for normal development and homeostasis, and their misbehavior may be related to the origin of cancer. Progress in these areas has been difficult because the mechanisms regulating stem cell lineages are not well understood. Here, we have investigated the role of the SHH-GLI pathway in the developing mouse neocortex. The results show that SHH signaling endogenously regulates the number of embryonic and postnatal mouse neocortical cells with stem cell properties, and controls precursor proliferation in a concentration-dependent manner in cooperation with EGF signaling. These findings identify a crucial mechanism for the regulation of the number of cells with stem cell properties that is unexpectedly conserved in different stem cell niches.
Key words: Hedgehog, GLI, Neocortical stem cells, Mouse
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
Related articles in Development:
This article has been cited by other articles:
|
|
 |
|
  G. W. Calloni, N. M. Le Douarin, and E. Dupin High frequency of cephalic neural crest cells shows coexistence of neurogenic, melanogenic, and osteogenic differentiation capacities PNAS, June 2, 2009; 106(22): 8947 - 8952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Ward, L. Lee, K. Graham, T. Satkunendran, K. Yoshikawa, E. Ling, L. Harper, R. Austin, E. Nieuwenhuis, I. D. Clarke, et al. Multipotent CD15+ Cancer Stem Cells in Patched-1-Deficient Mouse Medulloblastoma Cancer Res., June 1, 2009; 69(11): 4682 - 4690. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kasper, V. Jaks, M. Fiaschi, and R. Toftgard Hedgehog signalling in breast cancer Carcinogenesis, June 1, 2009; 30(6): 903 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Schnidar, M. Eberl, S. Klingler, D. Mangelberger, M. Kasper, C. Hauser-Kronberger, G. Regl, R. Kroismayr, R. Moriggl, M. Sibilia, et al. Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway Cancer Res., February 15, 2009; 69(4): 1284 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Wall, A. J. Mears, B. McNeill, C. Mazerolle, S. Thurig, Y. Wang, R. Kageyama, and V. A. Wallace Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity J. Cell Biol., January 12, 2009; 184(1): 101 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Takanaga, N. Tsuchida-Straeten, K. Nishide, A. Watanabe, H. Aburatani, and T. Kondo Gli2 Is a Novel Regulator of Sox2 Expression in Telencephalic Neuroepithelial Cells Stem Cells, January 1, 2009; 27(1): 165 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Komada, H. Saitsu, M. Kinboshi, T. Miura, K. Shiota, and M. Ishibashi Hedgehog signaling is involved in development of the neocortex Development, August 15, 2008; 135(16): 2717 - 2727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Lipinski, P. R. Hutson, P. W. Hannam, R. J. Nydza, I. M. Washington, R. W. Moore, G. G. Girdaukas, R. E. Peterson, and W. Bushman Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse Toxicol. Sci., July 1, 2008; 104(1): 189 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. B. Dirks Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer J. Clin. Oncol., June 10, 2008; 26(17): 2916 - 2924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Q. Doe Neural stem cells: balancing self-renewal with differentiation Development, May 1, 2008; 135(9): 1575 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Evangelista, H. Tian, and F. J de Sauvage The Hedgehog Signaling Pathway in Cancer Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 479 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Neill, W. J. Harrison, M. S. Ikram, T. D.L. Williams, L. S. Bianchi, S. K. Nadendla, J. L. Green, L. Ghali, A.-M. Frischauf, E. A. O'Toole, et al. GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes Carcinogenesis, April 1, 2008; 29(4): 738 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Louis, R. L. Rietze, L. Deleyrolle, R. E. Wagey, T. E. Thomas, A. C. Eaves, and B. A. Reynolds Enumeration of Neural Stem and Progenitor Cells in the Neural Colony-Forming Cell Assay Stem Cells, April 1, 2008; 26(4): 988 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Callejo, J. Culi, and I. Guerrero Patched, the receptor of Hedgehog, is a lipoprotein receptor PNAS, January 22, 2008; 105(3): 912 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. B Dirks Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells Phil Trans R Soc B, January 12, 2008; 363(1489): 139 - 152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Stecca, C. Mas, V. Clement, M. Zbinden, R. Correa, V. Piguet, F. Beermann, and A. Ruiz i Altaba Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways PNAS, April 3, 2007; 104(14): 5895 - 5900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Locker, M. Agathocleous, M. A. Amato, K. Parain, W. A. Harris, and M. Perron Hedgehog signaling and the retina: insights into the mechanisms controlling the proliferative properties of neural precursors. Genes & Dev., November 1, 2006; 20(21): 3036 - 3048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Evangelista, H. Tian, and F. J. de Sauvage The hedgehog signaling pathway in cancer. Clin. Cancer Res., October 15, 2006; 12(20): 5924 - 5928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes. Mol. Cell. Biol., August 1, 2006; 26(16): 6283 - 6298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-x. Zhou, L.-w. Jia, W.-m. Liu, C.-l. Miao, S. Liu, Y.-j. Cao, and E.-k. Duan Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis Hum. Reprod., July 1, 2006; 21(7): 1698 - 1704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Blaess, J. D. Corrales, and A. L. Joyner Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region Development, May 1, 2006; 133(9): 1799 - 1809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Corrales, S. Blaess, E. M. Mahoney, and A. L. Joyner The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation Development, May 1, 2006; 133(9): 1811 - 1821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-H. Lien, O. Klezovitch, T. E. Fernandez, J. Delrow, and V. Vasioukhin alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science, March 17, 2006; 311(5767): 1609 - 1612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cayuso, F. Ulloa, B. Cox, J. Briscoe, and E. Marti The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity Development, February 1, 2006; 133(3): 517 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Merchant, M. Evangelista, S.-M. Luoh, G. D. Frantz, S. Chalasani, R. A. D. Carano, M. van Hoy, J. Ramirez, A. K. Ogasawara, L. M. McFarland, et al. Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus Mol. Cell. Biol., August 15, 2005; 25(16): 7054 - 7068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba Cooperative requirement of the Gli proteins in neurogenesis Development, July 15, 2005; 132(14): 3267 - 3279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Palma, D. A. Lim, N. Dahmane, P. Sanchez, T. C. Brionne, C. D. Herzberg, Y. Gitton, A. Carleton, A. Alvarez-Buylla, and A. R. i Altaba Sonic hedgehog controls stem cell behavior in the postnatal and adult brain Development, January 15, 2005; 132(2): 335 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Corrales, G. L. Rocco, S. Blaess, Q. Guo, and A. L. Joyner Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development Development, November 15, 2004; 131(22): 5581 - 5590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Adolphe, M. Narang, T. Ellis, C. Wicking, P. Kaur, and B. Wainwright An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis Development, October 15, 2004; 131(20): 5009 - 5019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sanchez, A. M. Hernandez, B. Stecca, A. J. Kahler, A. M. DeGueme, A. Barrett, M. Beyna, M. W. Datta, S. Datta, and A. Ruiz i Altaba Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling PNAS, August 24, 2004; 101(34): 12561 - 12566. [Abstract] [Full Text] [PDF]
|
|
